Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
tRNA-specific adenosine deaminase; comEB- ComE operon protein 2 (185 aa)
Predicted Functional Partners:
Thymidylate synthase; Catalyzes the reductive methylation of 2’-deoxyuridine- 5’-monophosphate (dUMP) to 2’-deoxythymidine-5’-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis (318 aa)
comEC_Rec2- DNA internalization-related competence protein ComEC/Rec2 (773 aa)
annotation not available (195 aa)
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (208 aa)
annotation not available (199 aa)
annotation not available (222 aa)
Cmk- cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily (225 aa)
Endonuclease YhcR; 5’-nucleotidase, C-terminal domain protein (426 aa)
Endonuclease YhcR; 5’-nucleotidase, C-terminal domain protein (529 aa)