STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRK82565.1Diguanylate cyclase phosphodiesterase domain-containing protein. (398 aa)    
Predicted Functional Partners:
KRK83344.1
Diguanylate cyclase phosphodiesterase domain 2 containing protein.
 
 0.896
KRK82567.1
Diguanylate cyclase phosphodiesterase domain 2 containing protein.
 
 
 0.878
KRK81628.1
Diguanylate cyclase phosphodiesterase domain-containing protein.
 
 0.872
ribA
GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family.
    
 0.868
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
    
  0.852
KRK82421.1
Diguanylate cyclase phosphodiesterase domain-containing protein.
 
 
 0.843
KRK82419.1
Glycosyltransferase.
 
 
 0.540
KRK83024.1
Two-component response regulator.
 
 
 0.529
KRK83999.1
Transcription regulator.
  
 0.525
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
    
  0.483
Your Current Organism:
Lactobacillus paralimentarius
NCBI taxonomy Id: 1423788
Other names: L. paralimentarius DSM 19674, Lactobacillus paralimentarius DSM 19674
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.