STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (162 aa)    
Predicted Functional Partners:
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
  
 0.998
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
 
 0.980
aroE
Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
 
 
 0.969
aroQ
3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family.
   
 0.832
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.830
AHG73827.1
Dam; DNA adenine methylase PRK10904; Dam of Gammaproteobacteria UniRef RepID=Q9CLK4_PASMU.
  
    0.712
AHG73920.1
T-protein; Bifunctional chorismate mutase/prephenate dehydrogenase PRK11199; T-protein of Bacteria UniRef RepID=TYRA_HAEIN.
  
  
 0.662
X781_5710
Bifunctional chorismate mutase/prephenate dehydratase PRK10622; Bifunctional prephenate dehydratase/chorismate mutase of Gammaproteobacteria UniRef RepID=B8F6C2_HAEPS.
 
  
 0.614
trpC
Tryptophan biosynthesis protein TrpCF; Bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase PRK09427; Tryptophan biosynthesis protein TrpCF of Gammaproteobacteria UniRef RepID=TRPC_HAEIN.
 
   
 0.573
AHG73829.1
Shikimate kinase I; Similar to motif PRK05057; similar to CDD PRK05057, group Amino acid transport and metabolism [METABOLISM].
       0.572
Your Current Organism:
Mannheimia sp. USDAARSUSMARC1261
NCBI taxonomy Id: 1432056
Other names: M. sp. USDA-ARS-USMARC-1261, Mannheimia sp. USDA-ARS-USMARC-1261
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