STRINGSTRING
cca protein (Escherichia coli O157H7) - STRING interaction network
"cca" - Multifunctional CCA protein in Escherichia coli O157H7
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ccaMultifunctional CCA protein; Catalyzes the addition and repair of the essential 3’- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2’- nucleotidase and 2’,3’-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3’-CCA terminus degraded by intracellular RNases (412 aa)    
Predicted Functional Partners:
ygiM
Uncharacterized protein YgiM; Corresponds to locus_tag Z4408 (206 aa)
 
        0.928
apaH
Bis(5’-nucleosyl)-tetraphosphatase, symmetrical; Hydrolyzes diadenosine 5’,5’’’-P1,P4-tetraphosphate to yield ADP (282 aa)
 
   
  0.684
metG
Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (677 aa)
 
   
  0.645
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity (928 aa)
   
   
  0.632
holA
DNA polymerase III, delta subunit; Corresponds to locus_tag Z0787 (343 aa)
   
   
  0.609
rpmF
50S ribosomal protein L32; Corresponds to locus_tag Z1728; Belongs to the bacterial ribosomal protein bL32 family (57 aa)
 
        0.598
tilS
tRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine; Belongs to the tRNA(Ile)-lysidine synthase family (431 aa)
 
   
  0.580
lpxH
UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (240 aa)
 
        0.577
sspB
Stringent starvation protein B; Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth. The exact function of SspB is not yet known (By similarity) (165 aa)
   
          0.561
orn
Oligoribonuclease; 3’-to-5’ exoribonuclease specific for small oligoribonucleotides (181 aa)
 
   
  0.552
Your Current Organism:
Escherichia coli O157H7
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933, Escherichia coli O157H7
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