STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ileSIsoleucine tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (938 aa)    
Predicted Functional Partners:
proS
Proline tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves de [...]
   
 0.993
argS
Arginine tRNA synthetase; Residues 1 to 577 of 577 are 99.82 pct identical to residues 1 to 577 of 577 from Escherichia coli K-12 Strain MG1655: B1876.
  
 0.985
lysS
Lysine tRNA synthetase, constitutive; Residues 1 to 505 of 505 are 99.80 pct identical to residues 1 to 505 of 505 from Escherichia coli K-12 Strain MG1655: B2890; Belongs to the class-II aminoacyl-tRNA synthetase family.
 
 0.976
lysU
Lysine tRNA synthetase, inducible; Residues 1 to 505 of 505 are 100.00 pct identical to residues 1 to 505 of 505 from Escherichia coli K-12 Strain MG1655: B4129; Belongs to the class-II aminoacyl-tRNA synthetase family.
 
 0.976
leuS
Leucine tRNA synthetase; Residues 1 to 860 of 860 are 99.53 pct identical to residues 1 to 860 of 860 from Escherichia coli K-12 Strain MG1655: B0642; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
0.967
glnS
Glutamine tRNA synthetase; Residues 1 to 554 of 554 are 99.45 pct identical to residues 1 to 554 of 554 from Escherichia coli K-12 Strain MG1655: B0680.
  
 0.961
gltX
Glutamate tRNA synthetase, catalytic subunit; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
 
 0.948
pheT
Phenylalanine tRNA synthetase, beta-subunit; Residues 1 to 795 of 795 are 99.62 pct identical to residues 1 to 795 of 795 from Escherichia coli K-12 Strain MG1655: B1713; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
 
 0.946
serS
Serine tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).
 
  
 0.931
lspA
Prolipoprotein signal peptidase (SPase II); This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family.
 
  
 0.927
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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