node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
folE | folX | Z3409 | Z3565 | GTP cyclohydrolase I; Residues 1 to 222 of 222 are 100.00 pct identical to residues 1 to 222 of 222 from Escherichia coli K-12 Strain MG1655: B2153. | D-erythro-7,8-dihydroneopterin tri P epimerase; Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8-dihydromonapterin triphosphate (H2MTP). Is required for tetrahydromonapterin biosynthesis. | 0.977 |
folE | nudB | Z3409 | Z2917 | GTP cyclohydrolase I; Residues 1 to 222 of 222 are 100.00 pct identical to residues 1 to 222 of 222 from Escherichia coli K-12 Strain MG1655: B2153. | dATP pyrophosphohydrolase; Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP. | 0.913 |
folE | phoA | Z3409 | Z0479 | GTP cyclohydrolase I; Residues 1 to 222 of 222 are 100.00 pct identical to residues 1 to 222 of 222 from Escherichia coli K-12 Strain MG1655: B2153. | Alkaline phosphatase; Residues 1 to 494 of 494 are 99.59 pct identical to residues 1 to 494 of 494 from Escherichia coli K-12 Strain MG1655: B0383; Belongs to the alkaline phosphatase family. | 0.900 |
folE | ygcM | Z3409 | Z4075 | GTP cyclohydrolase I; Residues 1 to 222 of 222 are 100.00 pct identical to residues 1 to 222 of 222 from Escherichia coli K-12 Strain MG1655: B2153. | Putative 6-pyruvoyl tetrahydrobiopterin synthase; Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. | 0.994 |
folE | ygiG | Z3409 | Z4411 | GTP cyclohydrolase I; Residues 1 to 222 of 222 are 100.00 pct identical to residues 1 to 222 of 222 from Escherichia coli K-12 Strain MG1655: B2153. | Putative kinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.909 |
folX | folE | Z3565 | Z3409 | D-erythro-7,8-dihydroneopterin tri P epimerase; Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8-dihydromonapterin triphosphate (H2MTP). Is required for tetrahydromonapterin biosynthesis. | GTP cyclohydrolase I; Residues 1 to 222 of 222 are 100.00 pct identical to residues 1 to 222 of 222 from Escherichia coli K-12 Strain MG1655: B2153. | 0.977 |
folX | nudB | Z3565 | Z2917 | D-erythro-7,8-dihydroneopterin tri P epimerase; Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8-dihydromonapterin triphosphate (H2MTP). Is required for tetrahydromonapterin biosynthesis. | dATP pyrophosphohydrolase; Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP. | 0.901 |
folX | phoA | Z3565 | Z0479 | D-erythro-7,8-dihydroneopterin tri P epimerase; Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8-dihydromonapterin triphosphate (H2MTP). Is required for tetrahydromonapterin biosynthesis. | Alkaline phosphatase; Residues 1 to 494 of 494 are 99.59 pct identical to residues 1 to 494 of 494 from Escherichia coli K-12 Strain MG1655: B0383; Belongs to the alkaline phosphatase family. | 0.919 |
folX | ygcM | Z3565 | Z4075 | D-erythro-7,8-dihydroneopterin tri P epimerase; Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8-dihydromonapterin triphosphate (H2MTP). Is required for tetrahydromonapterin biosynthesis. | Putative 6-pyruvoyl tetrahydrobiopterin synthase; Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. | 0.916 |
nudB | folE | Z2917 | Z3409 | dATP pyrophosphohydrolase; Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP. | GTP cyclohydrolase I; Residues 1 to 222 of 222 are 100.00 pct identical to residues 1 to 222 of 222 from Escherichia coli K-12 Strain MG1655: B2153. | 0.913 |
nudB | folX | Z2917 | Z3565 | dATP pyrophosphohydrolase; Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP. | D-erythro-7,8-dihydroneopterin tri P epimerase; Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8-dihydromonapterin triphosphate (H2MTP). Is required for tetrahydromonapterin biosynthesis. | 0.901 |
nudB | phoA | Z2917 | Z0479 | dATP pyrophosphohydrolase; Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP. | Alkaline phosphatase; Residues 1 to 494 of 494 are 99.59 pct identical to residues 1 to 494 of 494 from Escherichia coli K-12 Strain MG1655: B0383; Belongs to the alkaline phosphatase family. | 0.909 |
nudB | ygcM | Z2917 | Z4075 | dATP pyrophosphohydrolase; Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP. | Putative 6-pyruvoyl tetrahydrobiopterin synthase; Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. | 0.902 |
phoA | folE | Z0479 | Z3409 | Alkaline phosphatase; Residues 1 to 494 of 494 are 99.59 pct identical to residues 1 to 494 of 494 from Escherichia coli K-12 Strain MG1655: B0383; Belongs to the alkaline phosphatase family. | GTP cyclohydrolase I; Residues 1 to 222 of 222 are 100.00 pct identical to residues 1 to 222 of 222 from Escherichia coli K-12 Strain MG1655: B2153. | 0.900 |
phoA | folX | Z0479 | Z3565 | Alkaline phosphatase; Residues 1 to 494 of 494 are 99.59 pct identical to residues 1 to 494 of 494 from Escherichia coli K-12 Strain MG1655: B0383; Belongs to the alkaline phosphatase family. | D-erythro-7,8-dihydroneopterin tri P epimerase; Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8-dihydromonapterin triphosphate (H2MTP). Is required for tetrahydromonapterin biosynthesis. | 0.919 |
phoA | nudB | Z0479 | Z2917 | Alkaline phosphatase; Residues 1 to 494 of 494 are 99.59 pct identical to residues 1 to 494 of 494 from Escherichia coli K-12 Strain MG1655: B0383; Belongs to the alkaline phosphatase family. | dATP pyrophosphohydrolase; Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP. | 0.909 |
phoA | secA | Z0479 | Z0108 | Alkaline phosphatase; Residues 1 to 494 of 494 are 99.59 pct identical to residues 1 to 494 of 494 from Escherichia coli K-12 Strain MG1655: B0383; Belongs to the alkaline phosphatase family. | Preprotein translocase; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.876 |
phoA | thiE | Z0479 | Z5568 | Alkaline phosphatase; Residues 1 to 494 of 494 are 99.59 pct identical to residues 1 to 494 of 494 from Escherichia coli K-12 Strain MG1655: B0383; Belongs to the alkaline phosphatase family. | Thiamin biosynthesis, thiazole moiety; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.901 |
phoA | thiL | Z0479 | Z0519 | Alkaline phosphatase; Residues 1 to 494 of 494 are 99.59 pct identical to residues 1 to 494 of 494 from Escherichia coli K-12 Strain MG1655: B0383; Belongs to the alkaline phosphatase family. | Thiamin-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.900 |
phoA | ycfN | Z0479 | Z1745 | Alkaline phosphatase; Residues 1 to 494 of 494 are 99.59 pct identical to residues 1 to 494 of 494 from Escherichia coli K-12 Strain MG1655: B0383; Belongs to the alkaline phosphatase family. | Putative beta-glucosidase; Catalyzes the phosphorylation of thiamine to thiamine phosphate. | 0.900 |