STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
yajBPutative glycoprotein; Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; Belongs to the AcpH family. (193 aa)    
Predicted Functional Partners:
coaA
Pantothenate kinase; Residues 1 to 308 of 308 are 100.00 pct identical to residues 9 to 316 of 316 from Escherichia coli K-12 Strain MG1655: B3974.
     
 0.944
acpS
CoA:apo-[acyl-carrier-protein] pantetheinephosphotransferase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to the 'Ser-36' of acyl-carrier-protein.
     
 0.928
kdtB
Putative enzyme of LPS biosynthesis; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
     
 0.922
acpS2
Putative acyl-carrier protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of an acyl-carrier-protein (By similarity). This isozyme may be involved into a specific lipid biosynthetic pathway that also includes Z1545, Z1546 and Z1547; Belongs to the P-Pant transferase superfamily. AcpS family.
     
 0.902
mazG
Orf, hypothetical protein; Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazE-MazF toxin- antitoxin (TA) system that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA (By similarity); Belongs to the nucleoside triphosphate py [...]
     
  0.900
acpT
Hypothetical protein; May be involved in an alternative pathway for phosphopantetheinyl transfer and holo-ACP synthesis in E.coli. The native apo-protein substrate is unknown. Is able to functionally replace AcpS in vivo but only when expressed at high levels. Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.
     
 0.900
dfp
Flavoprotein affecting synthesis of DNA and pantothenate metabolism; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
     
  0.900
ychM
Orf, hypothetical protein; Responsible for the aerobic transport of succinate from the periplasm to the cytoplasm at acidic pH; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
      
 0.614
queA
Synthesis of queuine in tRNA; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
       0.585
ydiF
Putative enzyme; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Exhibits high activity with acetoacetyl-CoA, propionyl-CoA, crotonoyl-CoA or butyryl- CoA as donors, with acetate as an acceptor. When acetyl-CoA is used as the donor, propionate, acetoacetate, butyrate, isobutyrate, and 4- hydroxybutyrate can be utilized as acceptors but not isovalerate. May play a role in short-chain fatty acid metabolism in E.coli.
      
 0.516
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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