STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mrdACell elongation, e phase; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (633 aa)    
Predicted Functional Partners:
mrdB
Rod shape-determining membrane protein; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily.
 
 0.999
mreC
Rod shape-determining protein; Residues 1 to 367 of 367 are 99.45 pct identical to residues 1 to 367 of 367 from Escherichia coli K-12 Strain MG1655: B3250.
 
 
 0.997
mrcA
Peptidoglycan synthetase; Residues 1 to 858 of 858 are 99.76 pct identical to residues 1 to 858 of 858 from Escherichia coli K-12 Strain MG1655: B3396.
  
 
 
 0.992
mreD
Rod shape-determining protein; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins (By similarity); Belongs to the MreD family.
 
  
 0.989
mreB
Regulator of ftsI, penicillin binding protein 3, septation function; Residues 1 to 367 of 367 are 100.00 pct identical to residues 1 to 367 of 367 from Escherichia coli K-12 Strain MG1655: B3251.
 
 
 
 0.983
ftsW
Cell division; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily.
 
 0.976
yfgA
Putative membrane protein; Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis.
   
 
 0.969
ftsI
Septum formation; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily.
  
  
0.946
mrcB
Peptidoglycan synthetase; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits).
 
 
 
 0.943
dacA
D-alanyl-D-alanine carboxypeptidase, fraction A; Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; Belongs to the peptidase S11 family.
 
  
 0.941
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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