node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acrR | cspD | Z0579 | Z1117 | acrAB operon repressor; Residues 1 to 215 of 215 are 99.53 pct identical to residues 1 to 215 of 215 from Escherichia coli K-12 Strain MG1655: B0464. | Cold shock protein; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity). | 0.492 |
cspD | acrR | Z1117 | Z0579 | Cold shock protein; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity). | acrAB operon repressor; Residues 1 to 215 of 215 are 99.53 pct identical to residues 1 to 215 of 215 from Escherichia coli K-12 Strain MG1655: B0464. | 0.492 |
cspD | dadA | Z1117 | Z1952 | Cold shock protein; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity). | D-amino acid dehydrogenase subunit; Oxidative deamination of D-amino acids; Belongs to the DadA oxidoreductase family. | 0.510 |
cspD | deaD | Z1117 | Z4523 | Cold shock protein; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity). | Inducible ATP-independent RNA helicase; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. | 0.552 |
cspD | mcbR | Z1117 | Z2269 | Cold shock protein; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity). | Orf, hypothetical protein; Residues 1 to 240 of 240 are 99.58 pct identical to residues 1 to 240 of 240 from Escherichia coli K-12 Strain MG1655: B1450. | 0.463 |
cspD | rmf | Z1117 | Z1303 | Cold shock protein; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity). | Ribosome modulation factor; During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes). May form immature 90S particles, which are converted to mature 100S ribosomes by the hibernation promoting factor Hpf. | 0.532 |
cspD | spy | Z1117 | Z2775 | Cold shock protein; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity). | Periplasmic protein related to spheroblast formation; An ATP-independent periplasmic chaperone, decreases protein aggregation and helps protein refolding. Binds substrate over a large region. Protect proteins in vitro against tannin inactivation; tannins have antimicrobial activity. Overexpression enhances the stability of otherwise unstable periplasmic proteins. Belongs to the CpxP/Spy family. | 0.463 |
cspD | uspA | Z1117 | Z4895 | Cold shock protein; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity). | Universal stress protein; Required for resistance to DNA-damaging agents. | 0.418 |
cspD | ychH | Z1117 | Z1976 | Cold shock protein; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity). | Orf, hypothetical protein; Residues 1 to 92 of 92 are 100.00 pct identical to residues 1 to 92 of 92 from Escherichia coli K-12 Strain MG1655: B1205. | 0.730 |
cspD | yljA | Z1117 | Z1118 | Cold shock protein; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity). | Orf, hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.474 |
cspD | ynaF | Z1117 | Z2335 | Cold shock protein; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity). | Hypothetical protein; Residues 1 to 168 of 168 are 99.40 pct identical to residues 1 to 168 of 168 from Escherichia coli K-12 Strain MG1655: B1376. | 0.537 |
dadA | cspD | Z1952 | Z1117 | D-amino acid dehydrogenase subunit; Oxidative deamination of D-amino acids; Belongs to the DadA oxidoreductase family. | Cold shock protein; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity). | 0.510 |
deaD | cspD | Z4523 | Z1117 | Inducible ATP-independent RNA helicase; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. | Cold shock protein; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity). | 0.552 |
mcbR | cspD | Z2269 | Z1117 | Orf, hypothetical protein; Residues 1 to 240 of 240 are 99.58 pct identical to residues 1 to 240 of 240 from Escherichia coli K-12 Strain MG1655: B1450. | Cold shock protein; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity). | 0.463 |
mcbR | spy | Z2269 | Z2775 | Orf, hypothetical protein; Residues 1 to 240 of 240 are 99.58 pct identical to residues 1 to 240 of 240 from Escherichia coli K-12 Strain MG1655: B1450. | Periplasmic protein related to spheroblast formation; An ATP-independent periplasmic chaperone, decreases protein aggregation and helps protein refolding. Binds substrate over a large region. Protect proteins in vitro against tannin inactivation; tannins have antimicrobial activity. Overexpression enhances the stability of otherwise unstable periplasmic proteins. Belongs to the CpxP/Spy family. | 0.465 |
rmf | cspD | Z1303 | Z1117 | Ribosome modulation factor; During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes). May form immature 90S particles, which are converted to mature 100S ribosomes by the hibernation promoting factor Hpf. | Cold shock protein; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity). | 0.532 |
spy | cspD | Z2775 | Z1117 | Periplasmic protein related to spheroblast formation; An ATP-independent periplasmic chaperone, decreases protein aggregation and helps protein refolding. Binds substrate over a large region. Protect proteins in vitro against tannin inactivation; tannins have antimicrobial activity. Overexpression enhances the stability of otherwise unstable periplasmic proteins. Belongs to the CpxP/Spy family. | Cold shock protein; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity). | 0.463 |
spy | mcbR | Z2775 | Z2269 | Periplasmic protein related to spheroblast formation; An ATP-independent periplasmic chaperone, decreases protein aggregation and helps protein refolding. Binds substrate over a large region. Protect proteins in vitro against tannin inactivation; tannins have antimicrobial activity. Overexpression enhances the stability of otherwise unstable periplasmic proteins. Belongs to the CpxP/Spy family. | Orf, hypothetical protein; Residues 1 to 240 of 240 are 99.58 pct identical to residues 1 to 240 of 240 from Escherichia coli K-12 Strain MG1655: B1450. | 0.465 |
uspA | cspD | Z4895 | Z1117 | Universal stress protein; Required for resistance to DNA-damaging agents. | Cold shock protein; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity). | 0.418 |
uspA | ynaF | Z4895 | Z2335 | Universal stress protein; Required for resistance to DNA-damaging agents. | Hypothetical protein; Residues 1 to 168 of 168 are 99.40 pct identical to residues 1 to 168 of 168 from Escherichia coli K-12 Strain MG1655: B1376. | 0.641 |