STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pncBNicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (400 aa)    
Predicted Functional Partners:
ydjB
Orf, hypothetical protein; Residues 1 to 219 of 219 are 99.08 pct identical to residues 1 to 219 of 219 from Escherichia coli K-12 Strain MG1655: B1768.
 
 
 0.990
nadC
Quinolinate phosphoribosyltransferase; Residues 1 to 297 of 297 are 99.66 pct identical to residues 1 to 297 of 297 from Escherichia coli K-12 Strain MG1655: B0109; Belongs to the NadC/ModD family.
   
 0.983
ybeN
Orf, hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
  
 
 0.981
nadR
Probable nadAB transcriptional regulator; Residues 1 to 417 of 417 are 99.52 pct identical to residues 1 to 417 of 417 from Escherichia coli K-12 Strain MG1655: B4390.
    
 0.977
ygaD
Orf, hypothetical protein; Residues 1 to 165 of 165 are 99.39 pct identical to residues 1 to 165 of 165 from Escherichia coli K-12 Strain MG1655: B2700; Belongs to the CinA family.
  
 
 0.963
yjaD
Orf, hypothetical protein; Residues 1 to 257 of 257 are 98.44 pct identical to residues 1 to 257 of 257 from Escherichia coli K-12 Strain MG1655: B3996.
    
 0.922
mazG
Orf, hypothetical protein; Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazE-MazF toxin- antitoxin (TA) system that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA (By similarity); Belongs to the nucleoside triphosphate py [...]
     
 0.915
asnS
Asparagine tRNA synthetase; Residues 1 to 466 of 466 are 99.57 pct identical to residues 1 to 466 of 466 from Escherichia coli K-12 Strain MG1655: B0930.
  
  
 0.912
deoD
Purine-nucleoside phosphorylase; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules; Belongs to the PNP/UDP phosphorylase family.
     
 0.912
yjjG
Putative phosphatase; Nucleotidase that shows high phosphatase activity toward non- canonical pyrimidine nucleotides and three canonical nucleoside 5'- monophosphates (UMP, dUMP, and dTMP), and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6-phosphogluconate. Appears to function as a house-cleaning nucleotidase in vivo, since the general nucleotidase activity of YjjG allows it to protect cells against non- canonical pyrimidine derivatives such as 5-fluoro-2'-deoxyuridine, 5- fluorouridine, 5-fluoroorotate, 5-fluorouracil, and 5-aza-2'- deoxycytidine, and prevents t [...]
   
 
 0.911
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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