STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
icdAIsocitrate dehydrogenase, specific for NADP+; Residues 1 to 416 of 416 are 99.27 pct identical to residues 1 to 416 of 416 from Escherichia coli K-12 Strain MG1655: B1136. (416 aa)    
Predicted Functional Partners:
aceK
Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
 
 
 
 0.988
acnA
Aconitate hydrase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.987
acnB
Aconitate hydrase B; Residues 1 to 865 of 865 are 99.88 pct identical to residues 1 to 865 of 865 from Escherichia coli K-12 Strain MG1655: B0118; Belongs to the aconitase/IPM isomerase family.
  
 
 0.983
sucA
2-oxoglutarate dehydrogenase (decarboxylase component); E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
   
 
 0.977
gltB
Glutamate synthase, large subunit; Residues 1 to 1517 of 1517 are 99.53 pct identical to residues 1 to 1517 of 1517 from Escherichia coli K-12 Strain MG1655: B3212.
    
 0.971
ybhJ
Putative enzyme; Residues 1 to 761 of 761 are 99.21 pct identical to residues 1 to 761 of 761 from Escherichia coli K-12 Strain MG1655: B0771.
  
 0.969
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate.
  
 
 0.965
gltA
Citrate synthase; Residues 1 to 426 of 427 are 99.76 pct identical to residues 1 to 426 of 427 from Escherichia coli K-12 Strain MG1655: B0720; Belongs to the citrate synthase family.
 
 
 0.964
aspC
Aspartate aminotransferase; Residues 1 to 396 of 396 are 99.49 pct identical to residues 1 to 396 of 396 from Escherichia coli K-12 Strain MG1655: B0928.
   
 0.956
gdhA
NADP-specific glutamate dehydrogenase; Residues 1 to 447 of 447 are 99.32 pct identical to residues 1 to 447 of 447 from Escherichia coli K-12 Strain MG1655: B1761; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.941
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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