STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
fabIEnoyl-[acyl-carrier-protein] reductase (NADH); Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis (By similarity). Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. (262 aa)    
Predicted Functional Partners:
fabD
malonyl-CoA-[acyl-carrier-protein] transacylase; Residues 1 to 309 of 309 are 99.35 pct identical to residues 1 to 309 of 309 from Escherichia coli K-12 Strain MG1655: B1092; Belongs to the FabD family.
 
 
 0.996
fabF
3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthesis (By similarity); Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
 
 
 0.996
fabB
3-oxoacyl-[acyl-carrier-protein] synthase I; Residues 1 to 406 of 406 are 99.50 pct identical to residues 1 to 406 of 406 from Escherichia coli K-12 Strain MG1655: B2323; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
 
 
 0.995
fabA
Beta-hydroxydecanoyl thioester dehydrase, trans-2-decenoyl-ACP isomerase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length (By similarity).
  
 
 0.989
fabZ
(3R)-hydroxymyristol acyl carrier protein dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity).
 
 
 0.985
fabF-3
Putative beta-ketoacyl-ACP synthase; Residues 3 to 408 of 409 are 55.09 pct identical to residues 2 to 412 of 414 from GenPept 118 : gi|1651213|dbj|BAA13559.1| (D88189) beta-ketoacyl-ACP synthase IV [Actinobacillus actinomycetemcomitans]; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
 
 
 0.979
fabF-2
Putative 3-oxoacyl-[ACP] synthase; Residues 4 to 384 of 389 are 31.29 pct identical to residues 8 to 403 of 407 from GenPept 118 : gi|2808747|emb|CAA16177.1| (AL021409) 3-oxoacyl-[acyl-carrier-protein] synthase [Streptomyces coelicolor A3(2)]; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
 
 
 0.977
fabH
3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
 
  
 0.965
fabG-2
Putative beta-ketoacyl-ACP reductase; Residues 1 to 242 of 243 are 57.02 pct identical to residues 1 to 241 of 242 from GenPept 118 : gi|7226957|gb|AAF42050.1| (AE002520) 3-oxoacyl-(acyl-carrier-protein) reductase [Neisseria meningitidis MC58].
  
 
 0.933
fabG
3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 
0.928
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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