STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
dcmDNA cytosine methylase; This methylase recognizes the double-stranded sequence CCWGG, causes specific methylation on C-2 on both strands; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (472 aa)    
Predicted Functional Partners:
vsr
DNA mismatch endonuclease, patch repair protein; May nick specific sequences that contain T:G mispairs resulting from m5C-deamination.
 
   
 0.977
dcm-2
Putative DNA modification methyltransferase encoded within prophage CP-933R; Residues 4 to 368 of 383 are 40.90 pct identical to residues 7 to 367 of 424 from GenPept 118 : gi|458402|gb|AAA50432.1| (U06424) M-XorII [Xanthomonas oryzae].
 
  
0.948
metK
Methionine adenosyltransferase 1 (AdoMet synthetase); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
    
 0.914
pfs
Orf, hypothetical protein; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP phospho [...]
    
  0.901
speD
S-adenosylmethionine decarboxylase; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
     
  0.900
dam
DNA adenine methylase; Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication; Belongs to the N(4)/N(6)-methyltransferase family.
     
 0.739
Z1847
Putative capsid protein of prophage CP-933C; Residues 3 to 380 of 385 are 57.03 pct identical to residues 11 to 400 of 402 from GenPept 118 : gi|6739663|gb|AAF27364.1|AF198256_18 (AF198256) phage phi-C31 gp36-like protein [Haemophilus influenzae].
  
  
 0.735
hicA
Hypothetical protein; No significant matches.
      
 0.701
Z2365
Putative DNA packaging protein of prophage CP-933R; Residues 59 to 164 of 169 are 42.72 pct identical to residues 60 to 163 of 168 from GenPept 118 : gi|3192684|gb|AAC19037.1| (AF064539) gp1 [Bacteriophage N15].
      
 0.692
yedJ
Orf, hypothetical protein; Residues 1 to 231 of 231 are 96.96 pct identical to residues 1 to 231 of 231 from Escherichia coli K-12 Strain MG1655: B1962.
     
 0.604
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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