STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
hisBImidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase; Residues 1 to 356 of 356 are 99.43 pct identical to residues 1 to 356 of 356 from Escherichia coli K-12 Strain MG1655: B2022; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (356 aa)    
Predicted Functional Partners:
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
 
  
 0.999
hisD
L-histidinal:NAD+ oxidoreductase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
 0.999
hisC
Histidinol-phosphate aminotransferase; Residues 1 to 356 of 356 are 99.43 pct identical to residues 1 to 356 of 356 from Escherichia coli K-12 Strain MG1655: B2021; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
 0.999
hisH
Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
 
 
 0.999
hisA
N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Residues 1 to 246 of 246 are 98.37 pct identical to residues 1 to 246 of 246 from Escherichia coli K-12 Strain MG1655: B2024; Belongs to the HisA/HisF family.
 
  
 0.999
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
 
 
 0.999
hisI
Phosphoribosyl-amp cyclohydrolase; Residues 1 to 203 of 203 are 98.52 pct identical to residues 1 to 203 of 203 from Escherichia coli K-12 Strain MG1655: B2026; In the C-terminal section; belongs to the PRA-PH family.
 
  
 0.999
trpC
N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase; Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).
 
  
 0.943
thrA
Aspartokinase I, homoserine dehydrogenase I; Residues 1 to 820 of 820 are 99.75 pct identical to residues 1 to 820 of 820 from Escherichia coli K-12 Strain MG1655: B0002; In the C-terminal section; belongs to the homoserine dehydrogenase family.
 
   
 0.873
metL
Aspartokinase II and homoserine dehydrogenase II; Residues 1 to 810 of 810 are 99.87 pct identical to residues 1 to 810 of 810 from Escherichia coli K-12 Strain MG1655: B3940; In the C-terminal section; belongs to the homoserine dehydrogenase family.
 
   
 0.854
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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