STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
dcd2'-deoxycytidine 5'-triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (193 aa)    
Predicted Functional Partners:
dut
Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
 
  
 0.964
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
 
 0.924
pyrG
CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
  
 
 0.923
mazG
Orf, hypothetical protein; Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazE-MazF toxin- antitoxin (TA) system that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA (By similarity); Belongs to the nucleoside triphosphate py [...]
     
 0.915
nrdD
Anaerobic ribonucleoside-triphosphate reductase; Residues 1 to 712 of 712 are 99.85 pct identical to residues 1 to 712 of 712 from Escherichia coli K-12 Strain MG1655: B4238.
    
 0.902
asmA
Suppressor of ompF assembly mutants; Residues 1 to 617 of 617 are 99.51 pct identical to residues 1 to 617 of 617 from Escherichia coli K-12 Strain MG1655: B2064.
       0.736
udk
Uridine/cytidine kinase; Residues 1 to 231 of 231 are 100.00 pct identical to residues 1 to 231 of 231 from Escherichia coli K-12 Strain MG1655: B2066; Belongs to the uridine kinase family.
     
 0.699
yifE
Orf, hypothetical protein; Residues 1 to 112 of 112 are 100.00 pct identical to residues 1 to 112 of 112 from Escherichia coli K-12 Strain MG1655: B3764; Belongs to the UPF0438 family.
  
     0.629
nrdA
Ribonucleoside diphosphate reductase 1, alpha subunit, B1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
 
   
 0.606
nrdB
Ribonucleoside diphosphage reductase 1, beta subunit, B2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis.
  
   
 0.542
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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