STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cddCytidine/deoxycytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (294 aa)    
Predicted Functional Partners:
udp
Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family.
 
 
 0.989
udk
Uridine/cytidine kinase; Residues 1 to 231 of 231 are 100.00 pct identical to residues 1 to 231 of 231 from Escherichia coli K-12 Strain MG1655: B2066; Belongs to the uridine kinase family.
    
 0.971
deoA
Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
 
 
 0.969
tdk
Thymidine kinase; Phosphorylates both thymidine and deoxyuridine.
    
 0.955
surE
Survival protein; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.
  
  
 0.925
deoD
Purine-nucleoside phosphorylase; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules; Belongs to the PNP/UDP phosphorylase family.
  
 
 0.925
yeiK
Orf, hypothetical protein; Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides; Belongs to the IUNH family. RihB subfamily.
   
 0.920
ushA
UDP-sugar hydrolase (5'-nucleotidase); Residues 1 to 550 of 550 are 99.27 pct identical to residues 1 to 550 of 550 from Escherichia coli K-12 Strain MG1655: B0480; Belongs to the 5'-nucleotidase family.
    
 0.909
cpdB
2':3'-cyclic-nucleotide 2'-phosphodiesterase; Residues 1 to 647 of 647 are 99.38 pct identical to residues 1 to 647 of 647 from Escherichia coli K-12 Strain MG1655: B4213; Belongs to the 5'-nucleotidase family.
    
 0.907
yaiE
Orf, hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.
     
 0.900
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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