STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hycIProtease involved in processing C-terminal end of the large subunit of hydrogenase 3; Protease involved in the C-terminal processing of HycE, the large subunit of hydrogenase 3. (156 aa)    
Predicted Functional Partners:
hycE
Large subunit of hydrogenase 3 (part of FHL complex); Residues 1 to 569 of 569 are 99.82 pct identical to residues 1 to 569 of 569 from Escherichia coli K-12 Strain MG1655: B2721.
 
  
 0.991
hycD
Membrane-spanning protein of hydrogenase 3 (part of FHL complex); Residues 1 to 307 of 307 are 99.67 pct identical to residues 1 to 307 of 307 from Escherichia coli K-12 Strain MG1655: B2722.
 
  
 0.982
hycH
Processing of large subunit (HycE) of hydrogenase 3 (part of the FHL complex); Seems to be required for the conversion of a precursor form of the large subunit of hydrogenlyase (HycE) into a mature form.
 
  
 0.979
hycF
Probable iron-sulfur protein of hydrogenase 3 (part of FHL complex); Residues 1 to 180 of 180 are 99.44 pct identical to residues 1 to 180 of 180 from Escherichia coli K-12 Strain MG1655: B2720.
 
  
 0.968
hycG
Hydrogenase activity; Residues 1 to 255 of 255 are 99.60 pct identical to residues 1 to 255 of 255 from Escherichia coli K-12 Strain MG1655: B2719.
 
  
 0.964
hyfG
Hydrogenase 4 subunit; Residues 1 to 571 of 571 are 96.84 pct identical to residues 1 to 555 of 555 from Escherichia coli K-12 Strain MG1655: B2487.
 
  
 0.951
hycC
Membrane-spanning protein of hydrogenase 3 (part of FHL complex); Residues 1 to 608 of 608 are 99.17 pct identical to residues 1 to 608 of 608 from Escherichia coli K-12 Strain MG1655: B2723.
 
  
 0.943
hycB
4Fe-4S dicluster domain-containing protein; Residues 1 to 203 of 203 are 99.50 pct identical to residues 1 to 203 of 203 from Escherichia coli K-12 Strain MG1655: B2724.
 
  
 0.920
hypF
Transcriptional regulatory protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.914
hycA
Transcriptional repression of hyc and hyp operons; Regulatory protein for the formate hydrogenlyase system. Could act by directly interacting with FhlA or by preventing the binding of FhlA to the upstream activatory sequence (By similarity).
  
  
 0.853
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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