STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
cysCAdenosine 5'-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate. (201 aa)    
Predicted Functional Partners:
cysN
ATP-sulfurylase (ATP:sulfate adenylyltransferase), subunit 1, probably a GTPase; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
 
 0.999
cysD
ATP:sulfurylase (ATP:sulfate adenylyltransferase), subunit 2; Residues 1 to 302 of 302 are 99.66 pct identical to residues 1 to 302 of 302 from Escherichia coli K-12 Strain MG1655: B2752.
 0.999
cysH
3'-phosphoadenosine 5'-phosphosulfate reductase; Reduction of activated sulfate into sulfite.
 0.999
cysQ
Affects pool of 3'-phosphoadenosine-5'-phosphosulfate in pathway of sulfite synthesis; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family.
 
 
 0.981
cysI
Sulfite reductase, alpha subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.980
cysJ
Sulfite reductase (NADPH), flavoprotein beta subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component; Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
  
 
 0.968
cysA
ATP-binding component of sulfate permease A protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system.
  
  
 0.967
cysG
Uroporphyrinogen III methylase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
 
  
 0.962
cysW
Sulfate/thiosulfate transport system permease W protein; Residues 1 to 149 of 149 are 99.32 pct identical to residues 1 to 149 of 149 from Escherichia coli K-12 Strain MG1655: B2423.
  
  
 0.903
cysM
Cysteine synthase B, O-acetylserine sulfhydrolase B; Residues 1 to 303 of 303 are 98.34 pct identical to residues 1 to 303 of 303 from Escherichia coli K-12 Strain MG1655: B2421; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
  
 0.879
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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