node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt | gmk | Z0586 | Z5074 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.939 |
apt | gpt | Z0586 | Z0299 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanine-hypoxanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.970 |
apt | guaA | Z0586 | Z3771 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.982 |
apt | guaC | Z0586 | Z0114 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.950 |
apt | hpt | Z0586 | Z0136 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine phosphoribosyltransferase; Residues 1 to 182 of 182 are 100.00 pct identical to residues 1 to 182 of 182 from Escherichia coli K-12 Strain MG1655: B0125; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.955 |
gmk | apt | Z5074 | Z0586 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.939 |
gmk | gpt | Z5074 | Z0299 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Guanine-hypoxanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.939 |
gmk | guaA | Z5074 | Z3771 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.982 |
gmk | guaC | Z5074 | Z0114 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.916 |
gmk | hpt | Z5074 | Z0136 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Hypoxanthine phosphoribosyltransferase; Residues 1 to 182 of 182 are 100.00 pct identical to residues 1 to 182 of 182 from Escherichia coli K-12 Strain MG1655: B0125; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.930 |
gmk | ndk | Z5074 | Z3781 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.927 |
gmk | pykA | Z5074 | Z2906 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Pyruvate kinase II, glucose stimulated; Residues 1 to 480 of 480 are 99.58 pct identical to residues 1 to 480 of 480 from Escherichia coli K-12 Strain MG1655: B1854; Belongs to the pyruvate kinase family. | 0.926 |
gmk | pykF | Z5074 | Z2704 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Pyruvate kinase I (formerly F), fructose stimulated; Residues 1 to 470 of 470 are 100.00 pct identical to residues 1 to 470 of 470 from Escherichia coli K-12 Strain MG1655: B1676. | 0.929 |
gmk | rpoZ | Z5074 | Z5075 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). | 0.955 |
gmk | spoT | Z5074 | Z5076 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | (p)ppGpp synthetase II; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp (By similarity); Belongs to the RelA/SpoT family. | 0.964 |
gpt | apt | Z0299 | Z0586 | Guanine-hypoxanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.970 |
gpt | gmk | Z0299 | Z5074 | Guanine-hypoxanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.939 |
gpt | guaA | Z0299 | Z3771 | Guanine-hypoxanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.982 |
gpt | guaC | Z0299 | Z0114 | Guanine-hypoxanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.936 |
gpt | hpt | Z0299 | Z0136 | Guanine-hypoxanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | Hypoxanthine phosphoribosyltransferase; Residues 1 to 182 of 182 are 100.00 pct identical to residues 1 to 182 of 182 from Escherichia coli K-12 Strain MG1655: B0125; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.964 |