STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Coexpression
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[Homology]
Score
yicEPutative transport protein; Specific, proton motive force-dependent high-affinity transporter for xanthine; Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. (463 aa)    
Predicted Functional Partners:
yicH
Orf, hypothetical protein; Residues 1 to 569 of 569 are 98.76 pct identical to residues 1 to 569 of 569 from Escherichia coli K-12 Strain MG1655: B3655.
      0.746
yieG
Putative membrane / transport protein; Residues 1 to 445 of 445 are 99.32 pct identical to residues 1 to 445 of 445 from Escherichia coli K-12 Strain MG1655: B3714.
 
  
 0.728
ghxQ
Hypothetical protein; Residues 6 to 455 of 455 are 82.44 pct identical to residues 1 to 449 of 449 from Escherichia coli K-12 Strain MG1655: B4064.
  
  
 0.689
yjcD
Orf, hypothetical protein; High-affinity transporter for guanine and hypoxanthine. Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily.
 
  
 0.689
purL
Phosphoribosylformyl-glycineamide synthetase = FGAM synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
  
 0.673
purM
Phosphoribosylaminoimidazole synthetase = AIR synthetase; Residues 1 to 345 of 345 are 99.13 pct identical to residues 1 to 345 of 345 from Escherichia coli K-12 Strain MG1655: B2499; Belongs to the AIR synthase family.
  
  
 0.631
purE
Phosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
  
 0.630
purK
Phosphoribosylaminoimidazole carboxylase = AIR carboxylase, CO(2)-fixing subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
  
  
 0.574
pyrB
Aspartate carbamoyltransferase, catalytic subunit; Residues 1 to 311 of 311 are 100.00 pct identical to residues 1 to 311 of 311 from Escherichia coli K-12 Strain MG1655: B4245; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
  
 0.564
purT
Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family.
   
  
 0.562
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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