STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
katGCatalase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (726 aa)    
Predicted Functional Partners:
katE
Catalase; Serves to protect cells from the toxic effects of hydrogen peroxide.
    
 0.983
hisC
Histidinol-phosphate aminotransferase; Residues 1 to 356 of 356 are 99.43 pct identical to residues 1 to 356 of 356 from Escherichia coli K-12 Strain MG1655: B2021; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
     
 0.915
aspC
Aspartate aminotransferase; Residues 1 to 396 of 396 are 99.49 pct identical to residues 1 to 396 of 396 from Escherichia coli K-12 Strain MG1655: B0928.
     
 0.905
tyrB
Tyrosine aminotransferase, tyrosine repressible; Residues 1 to 397 of 397 are 98.48 pct identical to residues 1 to 397 of 397 from Escherichia coli K-12 Strain MG1655: B4054.
     
 0.905
sodA
Superoxide dismutase, manganese; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family.
     
 0.903
yhhY
Orf, hypothetical protein; Residues 1 to 158 of 158 are 96.83 pct identical to residues 5 to 162 of 162 from Escherichia coli K-12 Strain MG1655: B3441.
     
  0.900
sodB
Superoxide dismutase, iron; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
     
 0.895
ahpC
Alkyl hydroperoxide reductase, C22 subunit; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  
  
 0.830
oxyR
Activator, hydrogen peroxide-inducible genes; Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstream of its own coding sequence. OxyR is inactivated by reduction of its essential disulfide bond by the product of GrxA, itself positively regulated by OxyR. Has also a positive regulatory effect on the production of surface proteins that control the colony morphology and auto- aggregation a [...]
     
 0.808
ydjB
Orf, hypothetical protein; Residues 1 to 219 of 219 are 99.08 pct identical to residues 1 to 219 of 219 from Escherichia coli K-12 Strain MG1655: B1768.
      
 0.801
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
Server load: medium (62%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.