STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (883 aa)    
Predicted Functional Partners:
pckA
Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
     
 0.979
gltA
Citrate synthase; Residues 1 to 426 of 427 are 99.76 pct identical to residues 1 to 426 of 427 from Escherichia coli K-12 Strain MG1655: B0720; Belongs to the citrate synthase family.
     
 0.970
ppsA
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
     
 0.961
pykF
Pyruvate kinase I (formerly F), fructose stimulated; Residues 1 to 470 of 470 are 100.00 pct identical to residues 1 to 470 of 470 from Escherichia coli K-12 Strain MG1655: B1676.
     
 0.956
pykA
Pyruvate kinase II, glucose stimulated; Residues 1 to 480 of 480 are 99.58 pct identical to residues 1 to 480 of 480 from Escherichia coli K-12 Strain MG1655: B1854; Belongs to the pyruvate kinase family.
     
 0.952
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate.
     
 0.951
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
   
 
 0.929
aceB
Malate synthase A; Residues 1 to 533 of 533 are 99.62 pct identical to residues 1 to 533 of 533 from Escherichia coli K-12 Strain MG1655: B4014; Belongs to the malate synthase family.
     
 0.919
yojH
Orf, hypothetical protein; Residues 1 to 548 of 548 are 99.63 pct identical to residues 1 to 548 of 548 from Escherichia coli K-12 Strain MG1655: B2210.
     
 0.915
fdoH
Formate dehydrogenase-O, iron-sulfur subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.
     
 0.849
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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