STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pepAAminopeptidase A/I; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. Required for plasmid ColE1 site-specific recombination but not in its aminopeptidase activity. Could act as a structural component of the putative nucleoprotein complex in which the Xer recombination reaction takes place (By similarity); Belongs to the peptidase M17 family. (503 aa)    
Predicted Functional Partners:
ggt
Gamma-glutamyltranspeptidase; Residues 1 to 581 of 581 are 98.27 pct identical to residues 1 to 580 of 580 from Escherichia coli K-12 Strain MG1655: B3447.
     
 0.973
pepD
Aminoacyl-histidine dipeptidase (peptidase D); Residues 1 to 485 of 485 are 99.58 pct identical to residues 1 to 485 of 485 from Escherichia coli K-12 Strain MG1655: B0237.
   
 
 0.971
pepN
Aminopeptidase N; Residues 1 to 870 of 870 are 99.19 pct identical to residues 1 to 870 of 870 from Escherichia coli K-12 Strain MG1655: B0932.
   
 0.952
gshB
Glutathione synthetase; Residues 1 to 315 of 315 are 100.00 pct identical to residues 1 to 315 of 316 from Escherichia coli K-12 Strain MG1655: B2947.
   
 
 0.948
pepB
Putative peptidase; Probably plays an important role in intracellular peptide degradation.
  
  
0.923
gshA
Gamma-glutamate-cysteine ligase; Residues 1 to 518 of 518 are 99.80 pct identical to residues 1 to 518 of 518 from Escherichia coli K-12 Strain MG1655: B2688; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
     
 0.906
ybdK
Orf, hypothetical protein; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
     
  0.900
chaC
Cation transport regulator; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.
     
 0.900
aspC
Aspartate aminotransferase; Residues 1 to 396 of 396 are 99.49 pct identical to residues 1 to 396 of 396 from Escherichia coli K-12 Strain MG1655: B0928.
    
 0.821
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.820
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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