STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (431 aa)    
Predicted Functional Partners:
ADY13970.1
Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; KEGG: bvu:BVU_1693 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; SMART: AICARFT/IMPCHase bienzyme, transformylase domain.
  
 0.999
ADY14612.1
Phosphoribosylamine/glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; KEGG: ssm:Spirs_3193 phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C-domain.
 
 0.998
purD
Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: phosphoribosylamine/glycine ligase; Belongs to the GARS family.
 
 0.997
purM
TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase-related protein; AIR synthase-related protein, C-terminal.
   
 0.995
ADY13968.1
TIGRFAM: Phosphoribosylformylglycinamidine synthase, FGAM; KEGG: mla:Mlab_0300 carbamoyl-phosphate synthase, large subunit; PFAM: AIR synthase-related protein, C-terminal.
 
 
 0.991
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
 
   
 0.951
purU
Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).
  
  
0.930
purE
Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
 
   
 0.929
folD
Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
  
  0.922
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
  
  0.915
Your Current Organism:
Sphaerochaeta globosa
NCBI taxonomy Id: 158189
Other names: S. globosa str. Buddy, Sphaerochaeta globosa str. Buddy, Sphaerochaeta sp. Buddy, Spirochaeta sp. Buddy
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