STRINGSTRING
mtnN protein (Staphylococcus aureus Mu50) - STRING interaction network
"mtnN" - 5'-methylthioadenosine nucleosidase in Staphylococcus aureus Mu50
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mtnN5’-methylthioadenosine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5’-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5’-methylthioribose and S-ribosylhomocysteine, respectively (228 aa)    
Predicted Functional Partners:
luxS
S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (156 aa)
 
   
  0.999
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme (398 aa)
     
 
  0.920
SAV1597
GTP-binding protein YqeH (366 aa)
              0.847
SAV1591
Hypothetical protein (238 aa)
   
        0.833
SAV1595
Hypothetical protein (96 aa)
              0.830
nadD
Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (189 aa)
              0.830
SAV1593
Hydrolase (194 aa)
              0.830
rsfS
Iojap family protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (117 aa)
              0.830
SAV1598
Lipase (175 aa)
              0.811
cysK
Cysteine synthase (310 aa)
         
  0.778
Your Current Organism:
Staphylococcus aureus Mu50
NCBI taxonomy Id: 158878
Other names: S. aureus subsp. aureus Mu50, Staphylococcus aureus (strain Mu50 / ATCC 700699), Staphylococcus aureus Mu50, Staphylococcus aureus subsp. aureus Mu50
Server load: low (7%) [HD]