node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Daro_0217 | Daro_0440 | Daro_0217 | Daro_0440 | Glutamate synthase (NADH) large subunit. | Dihydrolipoamide dehydrogenase. | 0.948 |
Daro_0217 | Daro_1809 | Daro_0217 | Daro_1809 | Glutamate synthase (NADH) large subunit. | Glycine cleavage H-protein. | 0.882 |
Daro_0217 | Daro_2857 | Daro_0217 | Daro_2857 | Glutamate synthase (NADH) large subunit. | Dihydrolipoamide dehydrogenase. | 0.893 |
Daro_0217 | gcvH | Daro_0217 | Daro_2464 | Glutamate synthase (NADH) large subunit. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.882 |
Daro_0217 | gcvP | Daro_0217 | Daro_2465 | Glutamate synthase (NADH) large subunit. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.959 |
Daro_0217 | gcvT | Daro_0217 | Daro_2463 | Glutamate synthase (NADH) large subunit. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.912 |
Daro_0217 | glyA | Daro_0217 | Daro_0603 | Glutamate synthase (NADH) large subunit. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.485 |
Daro_0217 | purL | Daro_0217 | Daro_1925 | Glutamate synthase (NADH) large subunit. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.551 |
Daro_0217 | sucC | Daro_0217 | Daro_3364 | Glutamate synthase (NADH) large subunit. | succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.529 |
Daro_0440 | Daro_0217 | Daro_0440 | Daro_0217 | Dihydrolipoamide dehydrogenase. | Glutamate synthase (NADH) large subunit. | 0.948 |
Daro_0440 | Daro_1809 | Daro_0440 | Daro_1809 | Dihydrolipoamide dehydrogenase. | Glycine cleavage H-protein. | 0.997 |
Daro_0440 | Daro_2857 | Daro_0440 | Daro_2857 | Dihydrolipoamide dehydrogenase. | Dihydrolipoamide dehydrogenase. | 0.995 |
Daro_0440 | gcvH | Daro_0440 | Daro_2464 | Dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.998 |
Daro_0440 | gcvP | Daro_0440 | Daro_2465 | Dihydrolipoamide dehydrogenase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.988 |
Daro_0440 | gcvT | Daro_0440 | Daro_2463 | Dihydrolipoamide dehydrogenase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.998 |
Daro_0440 | glyA | Daro_0440 | Daro_0603 | Dihydrolipoamide dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.970 |
Daro_0440 | purL | Daro_0440 | Daro_1925 | Dihydrolipoamide dehydrogenase. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.631 |
Daro_0440 | sucC | Daro_0440 | Daro_3364 | Dihydrolipoamide dehydrogenase. | succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.972 |
Daro_1809 | Daro_0217 | Daro_1809 | Daro_0217 | Glycine cleavage H-protein. | Glutamate synthase (NADH) large subunit. | 0.882 |
Daro_1809 | Daro_0440 | Daro_1809 | Daro_0440 | Glycine cleavage H-protein. | Dihydrolipoamide dehydrogenase. | 0.997 |