node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PP_0788 | cyaA | PP_0788 | PP_5222 | Homologs of previously reported genes of unknown function; Unknown function. | Adenylate cyclase; Function experimentally demonstrated in the studied strain; enzyme. | 0.840 |
cyaA | PP_0788 | PP_5222 | PP_0788 | Adenylate cyclase; Function experimentally demonstrated in the studied strain; enzyme. | Homologs of previously reported genes of unknown function; Unknown function. | 0.840 |
cyaA | mazG | PP_5222 | PP_1657 | Adenylate cyclase; Function experimentally demonstrated in the studied strain; enzyme. | Modified nucleoside triphosphate pyrophosphohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Purines, pyrimidines, nucleosides, and nucleotides. | 0.900 |
cyaA | moaA | PP_5222 | PP_4597 | Adenylate cyclase; Function experimentally demonstrated in the studied strain; enzyme. | Cyclic pyranopterin monophosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.803 |
cyaA | ndk | PP_5222 | PP_0849 | Adenylate cyclase; Function experimentally demonstrated in the studied strain; enzyme. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.900 |
cyaA | pde | PP_5222 | PP_4917 | Adenylate cyclase; Function experimentally demonstrated in the studied strain; enzyme. | 3',5'-cyclic-nucleotide phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | 0.983 |
cyaA | pyk | PP_5222 | PP_4301 | Adenylate cyclase; Function experimentally demonstrated in the studied strain; enzyme. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.920 |
cyaA | pykA | PP_5222 | PP_1362 | Adenylate cyclase; Function experimentally demonstrated in the studied strain; enzyme. | Pyruvate kinase II; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Anaerobic; Belongs to the pyruvate kinase family. | 0.900 |
cyaA | relA | PP_5222 | PP_1656 | Adenylate cyclase; Function experimentally demonstrated in the studied strain; enzyme. | ATP:GTP 3'-pyrophosphotransferase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.911 |
cyaA | ribAB-I | PP_5222 | PP_0516 | Adenylate cyclase; Function experimentally demonstrated in the studied strain; enzyme. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.800 |
cyaA | spoT | PP_5222 | PP_5302 | Adenylate cyclase; Function experimentally demonstrated in the studied strain; enzyme. | Bifunctional (p)ppGpp synthase/hydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.901 |
mazG | cyaA | PP_1657 | PP_5222 | Modified nucleoside triphosphate pyrophosphohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Purines, pyrimidines, nucleosides, and nucleotides. | Adenylate cyclase; Function experimentally demonstrated in the studied strain; enzyme. | 0.900 |
mazG | moaA | PP_1657 | PP_4597 | Modified nucleoside triphosphate pyrophosphohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Purines, pyrimidines, nucleosides, and nucleotides. | Cyclic pyranopterin monophosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.805 |
mazG | ndk | PP_1657 | PP_0849 | Modified nucleoside triphosphate pyrophosphohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Purines, pyrimidines, nucleosides, and nucleotides. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.900 |
mazG | pde | PP_1657 | PP_4917 | Modified nucleoside triphosphate pyrophosphohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Purines, pyrimidines, nucleosides, and nucleotides. | 3',5'-cyclic-nucleotide phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | 0.915 |
mazG | pyk | PP_1657 | PP_4301 | Modified nucleoside triphosphate pyrophosphohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Purines, pyrimidines, nucleosides, and nucleotides. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.900 |
mazG | pykA | PP_1657 | PP_1362 | Modified nucleoside triphosphate pyrophosphohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Purines, pyrimidines, nucleosides, and nucleotides. | Pyruvate kinase II; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Anaerobic; Belongs to the pyruvate kinase family. | 0.900 |
mazG | relA | PP_1657 | PP_1656 | Modified nucleoside triphosphate pyrophosphohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Purines, pyrimidines, nucleosides, and nucleotides. | ATP:GTP 3'-pyrophosphotransferase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.976 |
mazG | ribAB-I | PP_1657 | PP_0516 | Modified nucleoside triphosphate pyrophosphohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Purines, pyrimidines, nucleosides, and nucleotides. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.821 |
mazG | spoT | PP_1657 | PP_5302 | Modified nucleoside triphosphate pyrophosphohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Purines, pyrimidines, nucleosides, and nucleotides. | Bifunctional (p)ppGpp synthase/hydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.918 |