node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
XF_0560 | XF_1506 | XF_0560 | XF_1506 | GMP synthase; Similar to GI|6448738 (percent identity: 37 %/query alignment coverage: 90.8 %/subject alignment coverage: 93.6 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.902 |
XF_0560 | XF_2089 | XF_0560 | XF_2089 | GMP synthase; Similar to GI|6448738 (percent identity: 37 %/query alignment coverage: 90.8 %/subject alignment coverage: 93.6 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | 5'-nucleotidase; Similar to GI|4902474 (percent identity: 42 %/query alignment coverage: 98.7 %/subject alignment coverage: 88.0 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder/Start codon shift: -51. | 0.900 |
XF_0560 | XF_2354 | XF_0560 | XF_2354 | GMP synthase; Similar to GI|6448738 (percent identity: 37 %/query alignment coverage: 90.8 %/subject alignment coverage: 93.6 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | Hypoxanthine-guanine phosphoribosyltransferase; Similar to SP|Q02522 (percent identity: 27 %/query alignment coverage: 91.9 %/subject alignment coverage: 92.9 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | 0.912 |
XF_0560 | guaA | XF_0560 | XF_2429 | GMP synthase; Similar to GI|6448738 (percent identity: 37 %/query alignment coverage: 90.8 %/subject alignment coverage: 93.6 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | Glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. | 0.921 |
XF_0560 | guaB | XF_0560 | XF_2430 | GMP synthase; Similar to GI|6448738 (percent identity: 37 %/query alignment coverage: 90.8 %/subject alignment coverage: 93.6 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.965 |
XF_0560 | surE | XF_0560 | XF_0858 | GMP synthase; Similar to GI|6448738 (percent identity: 37 %/query alignment coverage: 90.8 %/subject alignment coverage: 93.6 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | Survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. | 0.910 |
XF_1506 | XF_0560 | XF_1506 | XF_0560 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase; Similar to GI|6448738 (percent identity: 37 %/query alignment coverage: 90.8 %/subject alignment coverage: 93.6 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | 0.902 |
XF_1506 | XF_1507 | XF_1506 | XF_1507 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Conserved hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.702 |
XF_1506 | XF_2089 | XF_1506 | XF_2089 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'-nucleotidase; Similar to GI|4902474 (percent identity: 42 %/query alignment coverage: 98.7 %/subject alignment coverage: 88.0 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder/Start codon shift: -51. | 0.900 |
XF_1506 | XF_2354 | XF_1506 | XF_2354 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypoxanthine-guanine phosphoribosyltransferase; Similar to SP|Q02522 (percent identity: 27 %/query alignment coverage: 91.9 %/subject alignment coverage: 92.9 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | 0.904 |
XF_1506 | guaA | XF_1506 | XF_2429 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. | 0.962 |
XF_1506 | guaB | XF_1506 | XF_2430 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.929 |
XF_1506 | ndk | XF_1506 | XF_0458 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.932 |
XF_1506 | nusG | XF_1506 | XF_2638 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Transcription antitermination factor; Participates in transcription elongation, termination and antitermination. | 0.562 |
XF_1506 | rph | XF_1506 | XF_1505 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.984 |
XF_1506 | surE | XF_1506 | XF_0858 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. | 0.900 |
XF_1507 | XF_1506 | XF_1507 | XF_1506 | Conserved hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.702 |
XF_1507 | rph | XF_1507 | XF_1505 | Conserved hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.412 |
XF_2089 | XF_0560 | XF_2089 | XF_0560 | 5'-nucleotidase; Similar to GI|4902474 (percent identity: 42 %/query alignment coverage: 98.7 %/subject alignment coverage: 88.0 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder/Start codon shift: -51. | GMP synthase; Similar to GI|6448738 (percent identity: 37 %/query alignment coverage: 90.8 %/subject alignment coverage: 93.6 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | 0.900 |
XF_2089 | XF_1506 | XF_2089 | XF_1506 | 5'-nucleotidase; Similar to GI|4902474 (percent identity: 42 %/query alignment coverage: 98.7 %/subject alignment coverage: 88.0 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder/Start codon shift: -51. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.900 |