node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
XF_1553 | folD | XF_1553 | XF_2431 | Adenylosuccinate lyase; Similar to SP|P44797 (percent identity: 57 %/query alignment coverage: 83.8 %/subject alignment coverage: 97.8 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.758 |
XF_1553 | glyA | XF_1553 | XF_0946 | Adenylosuccinate lyase; Similar to SP|P44797 (percent identity: 57 %/query alignment coverage: 83.8 %/subject alignment coverage: 97.8 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.802 |
XF_1553 | purA | XF_1553 | XF_0455 | Adenylosuccinate lyase; Similar to SP|P44797 (percent identity: 57 %/query alignment coverage: 83.8 %/subject alignment coverage: 97.8 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.988 |
XF_1553 | purD | XF_1553 | XF_1976 | Adenylosuccinate lyase; Similar to SP|P44797 (percent identity: 57 %/query alignment coverage: 83.8 %/subject alignment coverage: 97.8 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Glycinamide ribonucleotide synthetase; Similar to SP|P26977 (percent identity: 64 %/query alignment coverage: 97.7 %/subject alignment coverage: 99.5 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | 0.960 |
XF_1553 | purE | XF_1553 | XF_2672 | Adenylosuccinate lyase; Similar to SP|P44797 (percent identity: 57 %/query alignment coverage: 83.8 %/subject alignment coverage: 97.8 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.950 |
XF_1553 | purF | XF_1553 | XF_1949 | Adenylosuccinate lyase; Similar to SP|P44797 (percent identity: 57 %/query alignment coverage: 83.8 %/subject alignment coverage: 97.8 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.962 |
XF_1553 | purH | XF_1553 | XF_1975 | Adenylosuccinate lyase; Similar to SP|P44797 (percent identity: 57 %/query alignment coverage: 83.8 %/subject alignment coverage: 97.8 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Bifunctional purine biosynthesis protein; Similar to SP|P15639 (percent identity: 59 %/query alignment coverage: 91.3 %/subject alignment coverage: 99.1 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | 0.995 |
XF_1553 | purL | XF_1553 | XF_1423 | Adenylosuccinate lyase; Similar to SP|P44797 (percent identity: 57 %/query alignment coverage: 83.8 %/subject alignment coverage: 97.8 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylformylglycinamidine synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.998 |
XF_1553 | purM | XF_1553 | XF_0587 | Adenylosuccinate lyase; Similar to SP|P44797 (percent identity: 57 %/query alignment coverage: 83.8 %/subject alignment coverage: 97.8 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 5'-phosphoribosyl-5-aminoimidazole synthetase; Similar to SP|P08178 (percent identity: 59 %/query alignment coverage: 97.4 %/subject alignment coverage: 99.1 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder/Start codon shift: 117. | 0.863 |
XF_1553 | purN | XF_1553 | XF_0585 | Adenylosuccinate lyase; Similar to SP|P44797 (percent identity: 57 %/query alignment coverage: 83.8 %/subject alignment coverage: 97.8 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 5'-phosphoribosylglycinamide transformylase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.858 |
folD | XF_1553 | XF_2431 | XF_1553 | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Adenylosuccinate lyase; Similar to SP|P44797 (percent identity: 57 %/query alignment coverage: 83.8 %/subject alignment coverage: 97.8 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.758 |
folD | glyA | XF_2431 | XF_0946 | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.976 |
folD | purA | XF_2431 | XF_0455 | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.722 |
folD | purD | XF_2431 | XF_1976 | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycinamide ribonucleotide synthetase; Similar to SP|P26977 (percent identity: 64 %/query alignment coverage: 97.7 %/subject alignment coverage: 99.5 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | 0.522 |
folD | purE | XF_2431 | XF_2672 | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.458 |
folD | purF | XF_2431 | XF_1949 | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.492 |
folD | purH | XF_2431 | XF_1975 | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Bifunctional purine biosynthesis protein; Similar to SP|P15639 (percent identity: 59 %/query alignment coverage: 91.3 %/subject alignment coverage: 99.1 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder. | 0.972 |
folD | purL | XF_2431 | XF_1423 | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylformylglycinamidine synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.845 |
folD | purM | XF_2431 | XF_0587 | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 5'-phosphoribosyl-5-aminoimidazole synthetase; Similar to SP|P08178 (percent identity: 59 %/query alignment coverage: 97.4 %/subject alignment coverage: 99.1 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder/Start codon shift: 117. | 0.599 |
folD | purN | XF_2431 | XF_0585 | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 5'-phosphoribosylglycinamide transformylase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.966 |