STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dsbEC-type cytochrome biogenesis protein/thioredoxin; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity); Belongs to the thioredoxin family. DsbE subfamily. (197 aa)    
Predicted Functional Partners:
XF_2460
C-type cytochrome biogenesis membrane protein; Similar to SP|P52225 (percent identity: 52 %/query alignment coverage: 99.5 %/subject alignment coverage: 97.4 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder.
 
  
 0.992
XF_2462
C-type cytochrome biogenesis protein; Possible subunit of a heme lyase.
 
  
 0.972
XF_2463
Hypothetical protein; identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder.
 
  
 0.960
ccmC
Heme ABC transporter membrane protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.
 
  
 0.957
ccmE
C-type cytochrome biogenesis protein; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family.
 
  
 0.957
XF_2456
Heme ABC transporter membrane protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family.
 
  
 0.925
XF_0620
C-type cytochrome biogenesis protein (copper tolerance); Similar to GI|3329039 (percent identity: 32 %/query alignment coverage: 61.2 %/subject alignment coverage: 67.1 %); identified by sequence similarity; putative; ORF located using Glimmer/RBSfinder.
  
 
 0.901
XF_1530
Subunit C of alkyl hydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
  
 0.805
msrA
Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
   
 0.801
ccmA
Heme ABC transporter ATP-binding protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
 
   
 0.800
Your Current Organism:
Xylella fastidiosa
NCBI taxonomy Id: 160492
Other names: X. fastidiosa 9a5c, Xylella fastidiosa 9a5c
Server load: high (90%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.