STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KKT18873.1HAD-superfamily hydrolase, subfamily IA, variant 3. (201 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.920
KKT18874.1
Hypothetical protein.
  
 
 0.897
KKT19956.1
Hypothetical protein.
  
 
 0.870
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
 0.869
KKT19244.1
Glutamine-hydrolyzing GMP synthase.
    
  0.838
KKT19512.1
Hypothetical protein.
    
  0.743
KKT18618.1
DNA-binding helix-turn-helix protein.
    
  0.743
KKT19599.1
Hypothetical protein.
    
  0.727
KKT18872.1
Glucose 1-dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
     
 0.725
KKT18957.1
Polymerase protein.
     
 0.722
Your Current Organism:
Nomurabacteria bacterium GW2011GWB1437
NCBI taxonomy Id: 1618747
Other names: C. Nomurabacteria bacterium GW2011_GWB1_43_7, Candidatus Nomurabacteria bacterium GW2011_GWB1_43_7, Parcubacteria (Nomurabacteria) bacterium GW2011_GWB1_43_7
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