STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
acnBAconitate hydratase; Belongs to the aconitase/IPM isomerase family. (900 aa)    
Predicted Functional Partners:
gltA
Citrate synthase; Belongs to the citrate synthase family.
  
 
 0.986
icdA
Isocitrate dehydrogenase.
  
 
 0.981
acnA
Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
    
 0.942
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate.
  
  
 0.862
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
  
 0.843
sucA
2-oxoglutarate dehydrogenase E1 component.
   
  
 0.805
nuoC
NADH dehydrogenase I chain C/D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family.
   
    0.758
sdhC
Succinate dehydrogenase cytochrome b-556 subunit.
  
  
 0.629
sdhB
Succinate dehydrogenase, iron sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
  
 0.587
sdhA
Succinate dehydrogenase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
  
  
 0.579
Your Current Organism:
Erwinia gerundensis
NCBI taxonomy Id: 1619313
Other names: CCOS 903, CCOS:903, E. gerundensis, Erwinia gerundensis Rezzonico et al. 2016, Erwinia sp. 08-046A, Erwinia sp. 08-069A, Erwinia sp. 08-085C, Erwinia sp. 6-RJ-7B, Erwinia sp. EM406, Erwinia sp. EM436, Erwinia sp. EM477, Erwinia sp. EM486, Erwinia sp. EM573, Erwinia sp. EM595, Erwinia sp. EM603, Erwinia sp. KAZ28, LMG 28990, LMG:28990, Pantoea sp. EM486, Pantoea sp. EM595, Pantoea sp. P10QLC, Pantoea sp. P8SAA, strain EM595
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