STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CEM61313.1DnaJ domain protein. (174 aa)    
Predicted Functional Partners:
dnaK
Chaperone Hsp70, co-chaperone with DnaJ; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.970
grpE
Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
 
 
 0.952
htpG
Chaperone protein HtpG; Molecular chaperone. Has ATPase activity.
 
 0.949
CEM60657.1
LysM domain protein.
  
 0.905
nifJ
Pyruvate-flavodoxin oxidoreductase.
   
 
 0.844
groL
Cpn60 chaperonin GroEL, large subunit of GroESL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.810
CEM60452.1
Peptidyl-prolyl cis-trans isomerase.
 
 
 0.806
adhR
HTH-type transcriptional regulator AdhR (fragment).
  
 
 0.796
CEM61314.1
Putative uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
       0.778
CEM61478.1
Pyridine nucleotide-disulfide oxidoreductase (modular protein).
  
 
 0.768
Your Current Organism:
Treponema phagedenis
NCBI taxonomy Id: 162
Other names: T. phagedenis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.