STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cysSCysteinyl-trna synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family (457 aa)    
Predicted Functional Partners:
valS
Valyl-trna synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner
 
  
 0.954
leuS
Leucyl-trna synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family
  
 
 0.946
ileS
Isoleucyl-trna synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
  
  
 0.925
polA
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
  
  
 0.923
serS
Seryl-trna synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec)
 
 
 0.898
infB
Translation initiation factor if-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
 
  
 0.893
tyrS
Tyrosyl-trna synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)
  
 
 0.863
metK
S-adenosylmethionine synthetase; Belongs to the AdoMet synthase family
  
  
 0.862
WD_0148
Conserved hypothetical protein; Uncharacterized protein; Identified by similarity to EGAD:132851
       0.859
WD_0150
Exopolysaccharide synthesis protein ExoD-related protein; Identified by similarity to GP:9957205
       0.856
Your Current Organism:
Wolbachia sp. Dme
NCBI taxonomy Id: 163164
Other names: W. endosymbiont of Drosophila melanogaster, Wolbachia (endosymbiont of Drosophila melanogaster), Wolbachia endosymbiont of Drosophila melanogaster, Wolbachia pipientis wMel, Wolbachia sp. wMel
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