STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRT71101.1Hypothetical protein. (419 aa)    
Predicted Functional Partners:
KRT70519.1
Integral membrane protein terc.
 
    0.901
KRT71102.1
Hypothetical protein.
 
    
0.816
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 
 0.802
purH
Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase.
    
  0.668
surE
Stationary phase survival protein SurE, 5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
  0.656
guaB
Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase), IMPDH, IMPD; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.574
hprT
Hypoxanthine-guanine phosphoribosyltransferase, HGPRTase, HGPRT; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
  0.540
purA
Adenylosuccinate synthetase (IMP--aspartate ligase), AdSS, AMPSase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
   
 
 0.530
rdgB
Nucleoside-triphosphatase, dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.522
apt
Apt, adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 
  0.511
Your Current Organism:
candidate division NC10 bacterium CSP15
NCBI taxonomy Id: 1640516
Other names: c. division NC10 bacterium CSP1-5, candidate division NC10 bacterium CSP1-5
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