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hisF protein (Prochlorococcus marinus MIT9515) - STRING interaction network
"hisF" - Imidazole glycerol phosphate synthase subunit HisF in Prochlorococcus marinus MIT9515
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Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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hisFImidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (257 aa)    
Predicted Functional Partners:
hisH
Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (205 aa)
  0.999
hisI
Histidine biosynthesis bifunctional protein HisIE; COG139 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; In the N-terminal section; belongs to the PRA-CH family (220 aa)
   
  0.999
hisB
COG131 Imidazoleglycerol-phosphate dehydratase [Amino acid transport and metabolism] (201 aa)
  0.999
hisA
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; COG106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism] (255 aa)
 
 
0.992
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (428 aa)
 
  0.992
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity; Belongs to the ATP phosphoribosyltransferase family. Short subfamily (212 aa)
 
 
  0.973
ABM72912.1
Putative imidazoleglycerol-phosphate dehydratase; COG546 Predicted phosphatases [General function prediction only] (267 aa)
       
  0.909
ABM71424.1
Aminotransferase; COG79 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism] (369 aa)
 
  0.879
purH
Bifunctional purine biosynthesis protein PurH; COG138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism] (517 aa)
   
 
    0.867
purB
COG15 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily (431 aa)
   
 
    0.825
Your Current Organism:
Prochlorococcus marinus MIT9515
NCBI taxonomy Id: 167542
Other names: P. marinus str. MIT 9515, Prochlorococcus marinus MIT9515, Prochlorococcus marinus str. MIT 9515
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