STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thrBHomoserine kinase:GHMP kinases putative ATP-binding domain; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (315 aa)    
Predicted Functional Partners:
thrA
Homoserine dehydrogenase:ACT domain; COG460 Homoserine dehydrogenase [Amino acid transport and metabolism].
 
 0.996
thrC
Threonine synthase: Pyridoxal-5'-phosphate-dependent enzymes, beta family; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
 
 
 0.975
purM
Phosphoribosyl formylglycinamidine cyclo-ligase; COG150 Phosphoribosylaminoimidazole (AIR) synthetase [Nucleotide transport and metabolism].
 
    
 0.907
metH
Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.906
ABM71678.1
COG626 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism].
 
 
 0.847
ilvE
Putative Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.832
cysE
COG1045 Serine acetyltransferase [Amino acid transport and metabolism].
     
 0.831
glk
COG837 Glucokinase [Carbohydrate transport and metabolism]; Belongs to the bacterial glucokinase family.
       0.828
trpS
Tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family.
  
  
 0.827
thrS
Threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
     
 0.823
Your Current Organism:
Prochlorococcus marinus MIT9515
NCBI taxonomy Id: 167542
Other names: P. marinus str. MIT 9515, Prochlorococcus marinus str. MIT 9515
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.