STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fumCFumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)    
Predicted Functional Partners:
sdhA
COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion].
 
 0.993
mqo
Putative malate/quinone oxidoreductase; COG579 Predicted dehydrogenase [General function prediction only].
    
 0.937
gltA
COG372 Citrate synthase [Energy production and conversion]; Belongs to the citrate synthase family.
   
 0.919
aspC
Aminotransferases class-I; COG436 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism].
    
 0.815
argH
Fumarate lyase:Delta crystallin; COG165 Argininosuccinate lyase [Amino acid transport and metabolism].
   
 
 0.814
purU
Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).
     
  0.800
purB
Fumarate lyase:Adenylosuccinate lyase; COG15 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
   
 
0.728
pdhC
Dihydrolipoamide acetyltransferase; COG508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion].
   
 
 0.567
gltB
Ferredoxin-dependent glutamate synthase, Fd-GOGAT; COG69 Glutamate synthase domain 2 [Amino acid transport and metabolism].
     
 0.552
icd
COG538 Isocitrate dehydrogenases [Energy production and conversion].
   
 
 0.546
Your Current Organism:
Prochlorococcus marinus MIT9301
NCBI taxonomy Id: 167546
Other names: P. marinus str. MIT 9301, Prochlorococcus marinus str. MIT 9301
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