node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dnaA | dnaE | CPS_0001 | CPS_1570 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA polymerase III, alpha subunit; Identified by similarity to SP:P10443; match to protein family HMM PF01336; match to protein family HMM PF02231; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | 0.783 |
dnaA | dnaN | CPS_0001 | CPS_0002 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.994 |
dnaA | dnaX | CPS_0001 | CPS_3744 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA polymerase III, gamma/tau subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.820 |
dnaA | polA | CPS_0001 | CPS_4978 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.483 |
dnaE | dnaA | CPS_1570 | CPS_0001 | DNA polymerase III, alpha subunit; Identified by similarity to SP:P10443; match to protein family HMM PF01336; match to protein family HMM PF02231; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | 0.783 |
dnaE | dnaN | CPS_1570 | CPS_0002 | DNA polymerase III, alpha subunit; Identified by similarity to SP:P10443; match to protein family HMM PF01336; match to protein family HMM PF02231; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.994 |
dnaE | dnaQ | CPS_1570 | CPS_2255 | DNA polymerase III, alpha subunit; Identified by similarity to SP:P10443; match to protein family HMM PF01336; match to protein family HMM PF02231; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. | 0.991 |
dnaE | dnaX | CPS_1570 | CPS_3744 | DNA polymerase III, alpha subunit; Identified by similarity to SP:P10443; match to protein family HMM PF01336; match to protein family HMM PF02231; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | DNA polymerase III, gamma/tau subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.997 |
dnaE | holA | CPS_1570 | CPS_1720 | DNA polymerase III, alpha subunit; Identified by similarity to SP:P10443; match to protein family HMM PF01336; match to protein family HMM PF02231; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | DNA polymerase III, delta subunit; Identified by similarity to SP:P28630; match to protein family HMM PF06144; match to protein family HMM TIGR01128. | 0.992 |
dnaE | holB | CPS_1570 | CPS_2303 | DNA polymerase III, alpha subunit; Identified by similarity to SP:P10443; match to protein family HMM PF01336; match to protein family HMM PF02231; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | DNA polymerase III, delta prime subunit; Identified by similarity to SP:P28631. | 0.982 |
dnaE | polA | CPS_1570 | CPS_4978 | DNA polymerase III, alpha subunit; Identified by similarity to SP:P10443; match to protein family HMM PF01336; match to protein family HMM PF02231; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.540 |
dnaN | dnaA | CPS_0002 | CPS_0001 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | 0.994 |
dnaN | dnaE | CPS_0002 | CPS_1570 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase III, alpha subunit; Identified by similarity to SP:P10443; match to protein family HMM PF01336; match to protein family HMM PF02231; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | 0.994 |
dnaN | dnaQ | CPS_0002 | CPS_2255 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. | 0.990 |
dnaN | dnaX | CPS_0002 | CPS_3744 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase III, gamma/tau subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.992 |
dnaN | holA | CPS_0002 | CPS_1720 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase III, delta subunit; Identified by similarity to SP:P28630; match to protein family HMM PF06144; match to protein family HMM TIGR01128. | 0.994 |
dnaN | holB | CPS_0002 | CPS_2303 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase III, delta prime subunit; Identified by similarity to SP:P28631. | 0.982 |
dnaN | lig | CPS_0002 | CPS_4404 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA ligase, ATP-dependent; Identified by match to protein family HMM PF01068. | 0.988 |
dnaN | mutS | CPS_0002 | CPS_4137 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.984 |
dnaN | polA | CPS_0002 | CPS_4978 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.994 |