node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PdhD | glnA | gene:17593711 | gene:17593956 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Highly similar to glutamine synthetases. | 0.905 |
PdhD | glyA | gene:17593711 | gene:17595250 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.905 |
PdhD | lmo0560 | gene:17593711 | gene:17593211 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Similar to NADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.923 |
PdhD | lmo1348 | gene:17593711 | gene:17594005 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.959 |
PdhD | lmo1349 | gene:17593711 | gene:17594006 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Probable glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.950 |
PdhD | lmo1350 | gene:17593711 | gene:17594007 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Probable glycine dehydrogenase (decarboxylating) subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.950 |
PdhD | lmo1371 | gene:17593711 | gene:17594028 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Dihydrolipoyl dehydrogenase; Similar to branched-chain alpha-keto acid dehydrogenase E3 subunit. | 0.951 |
PdhD | lmo1734 | gene:17593711 | gene:17594416 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Lmo1734 protein; Similar to glutamate synthase (large subunit). | 0.941 |
PdhD | lmo2425 | gene:17593711 | gene:17595135 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.971 |
PdhD | purL | gene:17593711 | gene:17594452 | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | Phosphoribosylformylglycinamidine synthase subunit PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] | 0.893 |
glnA | PdhD | gene:17593956 | gene:17593711 | Highly similar to glutamine synthetases. | Highly similar to dihydrolipoamide dehydrogenase, E3 subunit of pyruvate dehydrogenase complex. | 0.905 |
glnA | glyA | gene:17593956 | gene:17595250 | Highly similar to glutamine synthetases. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.849 |
glnA | lmo0560 | gene:17593956 | gene:17593211 | Highly similar to glutamine synthetases. | Similar to NADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.932 |
glnA | lmo1348 | gene:17593956 | gene:17594005 | Highly similar to glutamine synthetases. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.917 |
glnA | lmo1349 | gene:17593956 | gene:17594006 | Highly similar to glutamine synthetases. | Probable glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.951 |
glnA | lmo1350 | gene:17593956 | gene:17594007 | Highly similar to glutamine synthetases. | Probable glycine dehydrogenase (decarboxylating) subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.915 |
glnA | lmo1371 | gene:17593956 | gene:17594028 | Highly similar to glutamine synthetases. | Dihydrolipoyl dehydrogenase; Similar to branched-chain alpha-keto acid dehydrogenase E3 subunit. | 0.905 |
glnA | lmo1734 | gene:17593956 | gene:17594416 | Highly similar to glutamine synthetases. | Lmo1734 protein; Similar to glutamate synthase (large subunit). | 0.985 |
glnA | lmo2425 | gene:17593956 | gene:17595135 | Highly similar to glutamine synthetases. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.910 |
glnA | purL | gene:17593956 | gene:17594452 | Highly similar to glutamine synthetases. | Phosphoribosylformylglycinamidine synthase subunit PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] | 0.904 |