STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lmo2119Similar to unknown proteins. (452 aa)    
Predicted Functional Partners:
lmo2120
Diadenylate cyclase; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP). c-di-AMP is a signaling compound secreted into the host's cytosol where it triggers the cytosolic surveillance pathway (CSP), a host pathway of innate immunity characterized by expression of beta interferon (IFN-beta) and coregulated genes. Expression of truncated proteins (missing first 80 or 100 residues) in E.coli leads to c-di-AMP synthesis ; Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
 
  
 0.993
lmo1594
Septation ring formation regulator EzrA; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.
  
     0.689
lmo1624
Lmo1624 protein; Similar to putative transporters.
  
    0.669
lmo1888
Cell cycle protein GpsB; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation.
  
    0.650
lmo1345
ComG operon protein 3; Required for transformation and DNA binding.
  
    0.634
lmo1625
Lmo1625 protein; Similar to putative transporters.
  
    0.632
lmo1757
Lmo1757 protein.
  
     0.623
pbpB
PbpB protein; Similar to penicillin-binding protein 2B.
 
     0.615
lmo1501
UPF0473 protein lmo1501; Similar to unknown proteins; Belongs to the UPF0473 family.
  
    0.607
comFA
ComFA protein; Similar to late competence protein comFA.
  
     0.601
Your Current Organism:
Listeria monocytogenes
NCBI taxonomy Id: 169963
Other names: L. monocytogenes EGD-e, Listeria monocytogenes ATCC BAA-679, Listeria monocytogenes EGD-e, Listeria monocytogenes EGDe, Listeria monocytogenes str. EGD-e, Listeria monocytogenes strain EGD-e
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.