node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
comEB | lmo0130 | gene:17594140 | gene:17592766 | ComEB protein; Similar to B. subtilis ComEB protein. | Cell wall protein Lmo0130; Similar to 5'-nucleotidase, putative peptidoglycan bound protein (LPXTG motif). | 0.897 |
comEB | lmo1463 | gene:17594140 | gene:17594120 | ComEB protein; Similar to B. subtilis ComEB protein. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.429 |
comEB | lmo1691 | gene:17594140 | gene:17594372 | ComEB protein; Similar to B. subtilis ComEB protein. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.949 |
comEB | lmo1874 | gene:17594140 | gene:17594559 | ComEB protein; Similar to B. subtilis ComEB protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.942 |
comEB | lmo2544 | gene:17594140 | gene:17595255 | ComEB protein; Similar to B. subtilis ComEB protein. | Similar to thymidine kinase. | 0.932 |
comEB | lmo2693 | gene:17594140 | gene:17595410 | ComEB protein; Similar to B. subtilis ComEB protein. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.930 |
deoD | lmo0130 | gene:17594541 | gene:17592766 | Purine nucleoside phosphorylase. | Cell wall protein Lmo0130; Similar to 5'-nucleotidase, putative peptidoglycan bound protein (LPXTG motif). | 0.953 |
deoD | lmo1463 | gene:17594541 | gene:17594120 | Purine nucleoside phosphorylase. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.926 |
deoD | lmo2544 | gene:17594541 | gene:17595255 | Purine nucleoside phosphorylase. | Similar to thymidine kinase. | 0.923 |
deoD | pdp | gene:17594541 | gene:17594678 | Purine nucleoside phosphorylase. | Pdp protein; Similar to pyrimidine-nucleoside phosphorylase. | 0.942 |
deoD | pnp | gene:17594541 | gene:17594638 | Purine nucleoside phosphorylase. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.963 |
lmo0130 | comEB | gene:17592766 | gene:17594140 | Cell wall protein Lmo0130; Similar to 5'-nucleotidase, putative peptidoglycan bound protein (LPXTG motif). | ComEB protein; Similar to B. subtilis ComEB protein. | 0.897 |
lmo0130 | deoD | gene:17592766 | gene:17594541 | Cell wall protein Lmo0130; Similar to 5'-nucleotidase, putative peptidoglycan bound protein (LPXTG motif). | Purine nucleoside phosphorylase. | 0.953 |
lmo0130 | lmo1463 | gene:17592766 | gene:17594120 | Cell wall protein Lmo0130; Similar to 5'-nucleotidase, putative peptidoglycan bound protein (LPXTG motif). | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.902 |
lmo0130 | lmo1874 | gene:17592766 | gene:17594559 | Cell wall protein Lmo0130; Similar to 5'-nucleotidase, putative peptidoglycan bound protein (LPXTG motif). | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.899 |
lmo0130 | lmo2544 | gene:17592766 | gene:17595255 | Cell wall protein Lmo0130; Similar to 5'-nucleotidase, putative peptidoglycan bound protein (LPXTG motif). | Similar to thymidine kinase. | 0.909 |
lmo0130 | lmo2693 | gene:17592766 | gene:17595410 | Cell wall protein Lmo0130; Similar to 5'-nucleotidase, putative peptidoglycan bound protein (LPXTG motif). | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.925 |
lmo0130 | pdp | gene:17592766 | gene:17594678 | Cell wall protein Lmo0130; Similar to 5'-nucleotidase, putative peptidoglycan bound protein (LPXTG motif). | Pdp protein; Similar to pyrimidine-nucleoside phosphorylase. | 0.901 |
lmo0130 | pnp | gene:17592766 | gene:17594638 | Cell wall protein Lmo0130; Similar to 5'-nucleotidase, putative peptidoglycan bound protein (LPXTG motif). | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.954 |
lmo0130 | prf1 | gene:17592766 | gene:17595254 | Cell wall protein Lmo0130; Similar to 5'-nucleotidase, putative peptidoglycan bound protein (LPXTG motif). | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.426 |