STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (650 aa)    
Predicted Functional Partners:
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 
 0.982
SJZ48148.1
Topoisomerase-4 subunit A.
 
 
 0.966
SJZ40430.1
DNA polymerase-1.
  
 
 0.610
SJZ56632.1
DNA polymerase-3 subunit beta.
  
 
 0.602
SJZ49779.1
Chromosome segregation ATPase.
   
 
 0.562
SJZ49810.1
Chromosome segregation ATPase.
   
 
 0.562
SJZ45565.1
tRNA pseudouridine55 synthase; Belongs to the pseudouridine synthase TruB family.
  
   0.539
SJZ47181.1
SecD/SecF fusion protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
  
  
 0.517
smc
Chromosome segregation protein; Required for chromosome condensation and partitioning. Belongs to the SMC family.
   
 
 0.502
SJZ50578.1
Hypothetical protein.
   
 
 0.502
Your Current Organism:
Mycoplasma verecundum
NCBI taxonomy Id: 171291
Other names: ATCC 27862, M. verecundum, NCTC 10145
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