node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SERP0229 | SERP0230 | SERP0229 | SERP0230 | Conserved hypothetical protein; Identified by similarity to OMNI:SA0628. | Conserved hypothetical protein; Identified by similarity to OMNI:SA0629; match to protein family HMM PF04241. | 0.740 |
SERP0229 | SERP0232 | SERP0229 | SERP0232 | Conserved hypothetical protein; Identified by similarity to OMNI:SA0628. | Amino acid permease family protein; Identified by match to protein family HMM PF00324. | 0.797 |
SERP0229 | thiD-1 | SERP0229 | SERP0226 | Conserved hypothetical protein; Identified by similarity to OMNI:SA0628. | Phosphomethylpyrimidine kinase; Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates (By similarity); Belongs to the ThiD family. | 0.757 |
SERP0229 | ung | SERP0229 | SERP0228 | Conserved hypothetical protein; Identified by similarity to OMNI:SA0628. | uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.881 |
SERP0230 | SERP0229 | SERP0230 | SERP0229 | Conserved hypothetical protein; Identified by similarity to OMNI:SA0629; match to protein family HMM PF04241. | Conserved hypothetical protein; Identified by similarity to OMNI:SA0628. | 0.740 |
SERP0230 | SERP0232 | SERP0230 | SERP0232 | Conserved hypothetical protein; Identified by similarity to OMNI:SA0629; match to protein family HMM PF04241. | Amino acid permease family protein; Identified by match to protein family HMM PF00324. | 0.812 |
SERP0230 | thiD-1 | SERP0230 | SERP0226 | Conserved hypothetical protein; Identified by similarity to OMNI:SA0629; match to protein family HMM PF04241. | Phosphomethylpyrimidine kinase; Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates (By similarity); Belongs to the ThiD family. | 0.748 |
SERP0230 | ung | SERP0230 | SERP0228 | Conserved hypothetical protein; Identified by similarity to OMNI:SA0629; match to protein family HMM PF04241. | uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.748 |
SERP0232 | SERP0229 | SERP0232 | SERP0229 | Amino acid permease family protein; Identified by match to protein family HMM PF00324. | Conserved hypothetical protein; Identified by similarity to OMNI:SA0628. | 0.797 |
SERP0232 | SERP0230 | SERP0232 | SERP0230 | Amino acid permease family protein; Identified by match to protein family HMM PF00324. | Conserved hypothetical protein; Identified by similarity to OMNI:SA0629; match to protein family HMM PF04241. | 0.812 |
SERP0232 | thiD-1 | SERP0232 | SERP0226 | Amino acid permease family protein; Identified by match to protein family HMM PF00324. | Phosphomethylpyrimidine kinase; Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates (By similarity); Belongs to the ThiD family. | 0.724 |
SERP0232 | ung | SERP0232 | SERP0228 | Amino acid permease family protein; Identified by match to protein family HMM PF00324. | uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.795 |
SERP2070 | tenA | SERP2070 | SERP1701 | Thiamine-phosphate pyrophosphorylase, putative; Identified by similarity to EGAD:22506. | Transcriptional regulator, TenA family; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP). Is also able to catalyze the hydrolytic cleavage of thiamine; however, this thiaminase activity may not be physiologically relevant. Therefore, is probably involved in the regeneration of the thiamine pyrimidine from thiamine degraded products present in the [...] | 0.727 |
SERP2070 | thiD-1 | SERP2070 | SERP0226 | Thiamine-phosphate pyrophosphorylase, putative; Identified by similarity to EGAD:22506. | Phosphomethylpyrimidine kinase; Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates (By similarity); Belongs to the ThiD family. | 0.785 |
SERP2070 | thiE | SERP2070 | SERP1698 | Thiamine-phosphate pyrophosphorylase, putative; Identified by similarity to EGAD:22506. | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.921 |
SERP2070 | thiM | SERP2070 | SERP1699 | Thiamine-phosphate pyrophosphorylase, putative; Identified by similarity to EGAD:22506. | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.833 |
pdxS | pdxT | SERP0158 | SERP0159 | Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | Conserved hypothetical protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | 0.999 |
pdxS | thiD-1 | SERP0158 | SERP0226 | Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | Phosphomethylpyrimidine kinase; Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates (By similarity); Belongs to the ThiD family. | 0.915 |
pdxT | pdxS | SERP0159 | SERP0158 | Conserved hypothetical protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | 0.999 |
pdxT | thiD-1 | SERP0159 | SERP0226 | Conserved hypothetical protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | Phosphomethylpyrimidine kinase; Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates (By similarity); Belongs to the ThiD family. | 0.912 |