node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dat | hisC | SERP1309 | SERP0387 | D-alanine aminotransferase; Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction. The second half-reaction is the reverse of the first, transferring the amino group from the pyridoxamine to a second alpha-keto acid to form the product D-amino acid via a ping-pong mechanism. This is an important process in the formation of D-alanine and D-glutamate, which are essen [...] | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM PF00222; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.929 |
dat | hisIE | SERP1309 | SERP2300 | D-alanine aminotransferase; Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction. The second half-reaction is the reverse of the first, transferring the amino group from the pyridoxamine to a second alpha-keto acid to form the product D-amino acid via a ping-pong mechanism. This is an important process in the formation of D-alanine and D-glutamate, which are essen [...] | phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase; Identified by similarity to EGAD:8260; match to protein family HMM PF01502; match to protein family HMM PF01503; In the C-terminal section; belongs to the PRA-PH family. | 0.546 |
hisA | hisB | SERP2302 | SERP2304 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:107380; match to protein family HMM PF00475. | 0.998 |
hisA | hisC | SERP2302 | SERP0387 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM PF00222; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.916 |
hisA | hisD | SERP2302 | SERP2305 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.995 |
hisA | hisF | SERP2302 | SERP2301 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | SERP2302 | SERP2306 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.995 |
hisA | hisH | SERP2302 | SERP2303 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisIE | SERP2302 | SERP2300 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase; Identified by similarity to EGAD:8260; match to protein family HMM PF01502; match to protein family HMM PF01503; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
hisB | hisA | SERP2304 | SERP2302 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:107380; match to protein family HMM PF00475. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | 0.998 |
hisB | hisC | SERP2304 | SERP0387 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:107380; match to protein family HMM PF00475. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM PF00222; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | SERP2304 | SERP2305 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:107380; match to protein family HMM PF00475. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisF | SERP2304 | SERP2301 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:107380; match to protein family HMM PF00475. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | SERP2304 | SERP2306 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:107380; match to protein family HMM PF00475. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.996 |
hisB | hisH | SERP2304 | SERP2303 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:107380; match to protein family HMM PF00475. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisIE | SERP2304 | SERP2300 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:107380; match to protein family HMM PF00475. | phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase; Identified by similarity to EGAD:8260; match to protein family HMM PF01502; match to protein family HMM PF01503; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
hisC | dat | SERP0387 | SERP1309 | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM PF00222; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | D-alanine aminotransferase; Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction. The second half-reaction is the reverse of the first, transferring the amino group from the pyridoxamine to a second alpha-keto acid to form the product D-amino acid via a ping-pong mechanism. This is an important process in the formation of D-alanine and D-glutamate, which are essen [...] | 0.929 |
hisC | hisA | SERP0387 | SERP2302 | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM PF00222; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | 0.916 |
hisC | hisB | SERP0387 | SERP2304 | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM PF00222; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:107380; match to protein family HMM PF00475. | 0.999 |
hisC | hisD | SERP0387 | SERP2305 | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM PF00222; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.994 |