node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SERP1235 | clpX | SERP1235 | SERP1238 | hemX protein; Identified by similarity to EGAD:15411; match to protein family HMM PF01578. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.738 |
SERP1235 | engB | SERP1235 | SERP1237 | hemX protein; Identified by similarity to EGAD:15411; match to protein family HMM PF01578. | GTP-binding protein, EngB family; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | 0.784 |
SERP1235 | hemA | SERP1235 | SERP1236 | hemX protein; Identified by similarity to EGAD:15411; match to protein family HMM PF01578. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.934 |
SERP1235 | hemB | SERP1235 | SERP1232 | hemX protein; Identified by similarity to EGAD:15411; match to protein family HMM PF01578. | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | 0.881 |
SERP1235 | hemC | SERP1235 | SERP1234 | hemX protein; Identified by similarity to EGAD:15411; match to protein family HMM PF01578. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.918 |
SERP1235 | hemD | SERP1235 | SERP1233 | hemX protein; Identified by similarity to EGAD:15411; match to protein family HMM PF01578. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.922 |
SERP1235 | hemE | SERP1235 | SERP1368 | hemX protein; Identified by similarity to EGAD:15411; match to protein family HMM PF01578. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.448 |
SERP1235 | hemH | SERP1235 | SERP1367 | hemX protein; Identified by similarity to EGAD:15411; match to protein family HMM PF01578. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.407 |
SERP1235 | hemL-1 | SERP1235 | SERP1231 | hemX protein; Identified by similarity to EGAD:15411; match to protein family HMM PF01578. | Glutamate-1-semialdehyde-2,1-aminomutase; Identified by similarity to SP:O34092; match to protein family HMM PF00202; match to protein family HMM TIGR00713. | 0.853 |
clpX | SERP1235 | SERP1238 | SERP1235 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | hemX protein; Identified by similarity to EGAD:15411; match to protein family HMM PF01578. | 0.738 |
clpX | engB | SERP1238 | SERP1237 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | GTP-binding protein, EngB family; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | 0.819 |
clpX | hemA | SERP1238 | SERP1236 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.763 |
clpX | hemB | SERP1238 | SERP1232 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | 0.776 |
clpX | hemC | SERP1238 | SERP1234 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.731 |
clpX | hemD | SERP1238 | SERP1233 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.713 |
clpX | hemL-1 | SERP1238 | SERP1231 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Glutamate-1-semialdehyde-2,1-aminomutase; Identified by similarity to SP:O34092; match to protein family HMM PF00202; match to protein family HMM TIGR00713. | 0.715 |
engB | SERP1235 | SERP1237 | SERP1235 | GTP-binding protein, EngB family; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | hemX protein; Identified by similarity to EGAD:15411; match to protein family HMM PF01578. | 0.784 |
engB | clpX | SERP1237 | SERP1238 | GTP-binding protein, EngB family; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.819 |
engB | hemA | SERP1237 | SERP1236 | GTP-binding protein, EngB family; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.796 |
engB | hemB | SERP1237 | SERP1232 | GTP-binding protein, EngB family; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | 0.741 |