node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SERP0786 | rsbW | SERP0786 | SERP1678 | Serine/threonine protein kinase, putative; Identified by match to protein family HMM PF00069; match to protein family HMM PF03793. | Anti-sigma B factor; Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B). | 0.701 |
SERP1407 | rpoF | SERP1407 | SERP1677 | Conserved hypothetical protein; Identified by similarity to OMNI:SA1927; match to protein family HMM PF04307. | RNA polymerase sigma-37 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.631 |
SERP1407 | rsbU | SERP1407 | SERP1680 | Conserved hypothetical protein; Identified by similarity to OMNI:SA1927; match to protein family HMM PF04307. | Sigma factor B regulator protein; Identified by similarity to GP:1729794. | 0.611 |
SERP1407 | rsbW | SERP1407 | SERP1678 | Conserved hypothetical protein; Identified by similarity to OMNI:SA1927; match to protein family HMM PF04307. | Anti-sigma B factor; Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B). | 0.666 |
SERP1675 | SERP1676 | SERP1675 | SERP1676 | Ribosomal protein, L40 family; Identified by match to protein family HMM PF03926; Belongs to the SprT family. | S1 RNA binding domain protein; Identified by similarity to EGAD:101821; match to protein family HMM PF00575. | 0.899 |
SERP1675 | rpoF | SERP1675 | SERP1677 | Ribosomal protein, L40 family; Identified by match to protein family HMM PF03926; Belongs to the SprT family. | RNA polymerase sigma-37 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.776 |
SERP1675 | rsbU | SERP1675 | SERP1680 | Ribosomal protein, L40 family; Identified by match to protein family HMM PF03926; Belongs to the SprT family. | Sigma factor B regulator protein; Identified by similarity to GP:1729794. | 0.736 |
SERP1675 | rsbV | SERP1675 | SERP1679 | Ribosomal protein, L40 family; Identified by match to protein family HMM PF03926; Belongs to the SprT family. | Anti-anti-sigma factor RsbV; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity); Belongs to the anti-sigma-factor antagonist family. | 0.776 |
SERP1675 | rsbW | SERP1675 | SERP1678 | Ribosomal protein, L40 family; Identified by match to protein family HMM PF03926; Belongs to the SprT family. | Anti-sigma B factor; Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B). | 0.776 |
SERP1676 | SERP1675 | SERP1676 | SERP1675 | S1 RNA binding domain protein; Identified by similarity to EGAD:101821; match to protein family HMM PF00575. | Ribosomal protein, L40 family; Identified by match to protein family HMM PF03926; Belongs to the SprT family. | 0.899 |
SERP1676 | rpoF | SERP1676 | SERP1677 | S1 RNA binding domain protein; Identified by similarity to EGAD:101821; match to protein family HMM PF00575. | RNA polymerase sigma-37 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.776 |
SERP1676 | rsbU | SERP1676 | SERP1680 | S1 RNA binding domain protein; Identified by similarity to EGAD:101821; match to protein family HMM PF00575. | Sigma factor B regulator protein; Identified by similarity to GP:1729794. | 0.736 |
SERP1676 | rsbV | SERP1676 | SERP1679 | S1 RNA binding domain protein; Identified by similarity to EGAD:101821; match to protein family HMM PF00575. | Anti-anti-sigma factor RsbV; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity); Belongs to the anti-sigma-factor antagonist family. | 0.782 |
SERP1676 | rsbW | SERP1676 | SERP1678 | S1 RNA binding domain protein; Identified by similarity to EGAD:101821; match to protein family HMM PF00575. | Anti-sigma B factor; Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B). | 0.776 |
alr | mazE | SERP1683 | SERP1682 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Conserved hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to cognate MazF toxin and counteracts its endoribonuclease activity; Belongs to the MazE/EndoAI family. | 0.828 |
alr | mazF | SERP1683 | SERP1681 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Transcriptional regulator, PemK family; Toxic component of a type II toxin-antitoxin (TA) system. Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis. It cuts between the first and nucleotides of 5'-UACAU-3' in single- stranded RNA. Neutralized by coexpression with cognate antitoxin MazE. Belongs to the PemK/MazF family. | 0.828 |
alr | rpoF | SERP1683 | SERP1677 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | RNA polymerase sigma-37 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.661 |
alr | rsbU | SERP1683 | SERP1680 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Sigma factor B regulator protein; Identified by similarity to GP:1729794. | 0.749 |
alr | rsbV | SERP1683 | SERP1679 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Anti-anti-sigma factor RsbV; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity); Belongs to the anti-sigma-factor antagonist family. | 0.676 |
alr | rsbW | SERP1683 | SERP1678 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Anti-sigma B factor; Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B). | 0.709 |