node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SERP0862 | tenA | SERP0862 | SERP1701 | Conserved hypothetical protein; Identified by similarity to OMNI:SA1314. | Transcriptional regulator, TenA family; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP). Is also able to catalyze the hydrolytic cleavage of thiamine; however, this thiaminase activity may not be physiologically relevant. Therefore, is probably involved in the regeneration of the thiamine pyrimidine from thiamine degraded products present in the [...] | 0.584 |
SERP0862 | thiE | SERP0862 | SERP1698 | Conserved hypothetical protein; Identified by similarity to OMNI:SA1314. | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.435 |
SERP0862 | thiM | SERP0862 | SERP1699 | Conserved hypothetical protein; Identified by similarity to OMNI:SA1314. | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.466 |
SERP2070 | tenA | SERP2070 | SERP1701 | Thiamine-phosphate pyrophosphorylase, putative; Identified by similarity to EGAD:22506. | Transcriptional regulator, TenA family; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP). Is also able to catalyze the hydrolytic cleavage of thiamine; however, this thiaminase activity may not be physiologically relevant. Therefore, is probably involved in the regeneration of the thiamine pyrimidine from thiamine degraded products present in the [...] | 0.727 |
SERP2070 | thiD-1 | SERP2070 | SERP0226 | Thiamine-phosphate pyrophosphorylase, putative; Identified by similarity to EGAD:22506. | Phosphomethylpyrimidine kinase; Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates (By similarity); Belongs to the ThiD family. | 0.785 |
SERP2070 | thiD-2 | SERP2070 | SERP1700 | Thiamine-phosphate pyrophosphorylase, putative; Identified by similarity to EGAD:22506. | Phosphomethylpyrimidine kinase; Identified by similarity to EGAD:97546; match to protein family HMM PF00294; match to protein family HMM TIGR00097. | 0.797 |
SERP2070 | thiE | SERP2070 | SERP1698 | Thiamine-phosphate pyrophosphorylase, putative; Identified by similarity to EGAD:22506. | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.921 |
SERP2070 | thiG | SERP2070 | SERP2073 | Thiamine-phosphate pyrophosphorylase, putative; Identified by similarity to EGAD:22506. | thiG protein, putative; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.997 |
SERP2070 | thiM | SERP2070 | SERP1699 | Thiamine-phosphate pyrophosphorylase, putative; Identified by similarity to EGAD:22506. | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.833 |
SERP2070 | thiS | SERP2070 | SERP2072 | Thiamine-phosphate pyrophosphorylase, putative; Identified by similarity to EGAD:22506. | Thiamine biosynthesis protein ThiS; Identified by similarity to EGAD:143246; match to protein family HMM PF02597; match to protein family HMM TIGR01683. | 0.949 |
ribD | thiD-1 | SERP1328 | SERP0226 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Phosphomethylpyrimidine kinase; Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates (By similarity); Belongs to the ThiD family. | 0.446 |
ribD | thiD-2 | SERP1328 | SERP1700 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Phosphomethylpyrimidine kinase; Identified by similarity to EGAD:97546; match to protein family HMM PF00294; match to protein family HMM TIGR00097. | 0.446 |
ribD | thiE | SERP1328 | SERP1698 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.596 |
ribD | thiM | SERP1328 | SERP1699 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. | 0.625 |
tenA | SERP0862 | SERP1701 | SERP0862 | Transcriptional regulator, TenA family; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP). Is also able to catalyze the hydrolytic cleavage of thiamine; however, this thiaminase activity may not be physiologically relevant. Therefore, is probably involved in the regeneration of the thiamine pyrimidine from thiamine degraded products present in the [...] | Conserved hypothetical protein; Identified by similarity to OMNI:SA1314. | 0.584 |
tenA | SERP2070 | SERP1701 | SERP2070 | Transcriptional regulator, TenA family; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP). Is also able to catalyze the hydrolytic cleavage of thiamine; however, this thiaminase activity may not be physiologically relevant. Therefore, is probably involved in the regeneration of the thiamine pyrimidine from thiamine degraded products present in the [...] | Thiamine-phosphate pyrophosphorylase, putative; Identified by similarity to EGAD:22506. | 0.727 |
tenA | thiD-1 | SERP1701 | SERP0226 | Transcriptional regulator, TenA family; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP). Is also able to catalyze the hydrolytic cleavage of thiamine; however, this thiaminase activity may not be physiologically relevant. Therefore, is probably involved in the regeneration of the thiamine pyrimidine from thiamine degraded products present in the [...] | Phosphomethylpyrimidine kinase; Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates (By similarity); Belongs to the ThiD family. | 0.863 |
tenA | thiD-2 | SERP1701 | SERP1700 | Transcriptional regulator, TenA family; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP). Is also able to catalyze the hydrolytic cleavage of thiamine; however, this thiaminase activity may not be physiologically relevant. Therefore, is probably involved in the regeneration of the thiamine pyrimidine from thiamine degraded products present in the [...] | Phosphomethylpyrimidine kinase; Identified by similarity to EGAD:97546; match to protein family HMM PF00294; match to protein family HMM TIGR00097. | 0.997 |
tenA | thiE | SERP1701 | SERP1698 | Transcriptional regulator, TenA family; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP). Is also able to catalyze the hydrolytic cleavage of thiamine; however, this thiaminase activity may not be physiologically relevant. Therefore, is probably involved in the regeneration of the thiamine pyrimidine from thiamine degraded products present in the [...] | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.977 |
tenA | thiG | SERP1701 | SERP2073 | Transcriptional regulator, TenA family; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP). Is also able to catalyze the hydrolytic cleavage of thiamine; however, this thiaminase activity may not be physiologically relevant. Therefore, is probably involved in the regeneration of the thiamine pyrimidine from thiamine degraded products present in the [...] | thiG protein, putative; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.571 |