node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
agrA | lytS | SERP1493 | SERP2024 | Accessory gene regulator protein A; Required for high-level post-exponential phase expression of a series of secreted proteins. | Sensor histidine kinase LytS; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. | 0.546 |
arlR | lytS | SERP0989 | SERP2024 | DNA-binding response regulator ArlR; Member of the two-component regulatory system ArlS/ArlR. | Sensor histidine kinase LytS; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. | 0.436 |
cidB | lrgA | SERP2116 | SERP2026 | Conserved hypothetical protein TIGR00659; Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidAB proteins. When a cell is stressed by the addition of antibiotics or by other factors in the environment, the CidAB proteins possibly oligomerize within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are a [...] | Holin-like protein LrgA; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidA/LrgA family. LrgA subfamily. | 0.982 |
cidB | lytR | SERP2116 | SERP2025 | Conserved hypothetical protein TIGR00659; Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidAB proteins. When a cell is stressed by the addition of antibiotics or by other factors in the environment, the CidAB proteins possibly oligomerize within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are a [...] | Response regulator LytR; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. | 0.441 |
cidB | lytS | SERP2116 | SERP2024 | Conserved hypothetical protein TIGR00659; Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidAB proteins. When a cell is stressed by the addition of antibiotics or by other factors in the environment, the CidAB proteins possibly oligomerize within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are a [...] | Sensor histidine kinase LytS; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. | 0.676 |
lrgA | cidB | SERP2026 | SERP2116 | Holin-like protein LrgA; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidA/LrgA family. LrgA subfamily. | Conserved hypothetical protein TIGR00659; Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidAB proteins. When a cell is stressed by the addition of antibiotics or by other factors in the environment, the CidAB proteins possibly oligomerize within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are a [...] | 0.982 |
lrgA | lrgB | SERP2026 | SERP2027 | Holin-like protein LrgA; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidA/LrgA family. LrgA subfamily. | lrgB protein; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidB/LrgB family. LrgB subfamily. | 0.998 |
lrgA | lytR | SERP2026 | SERP2025 | Holin-like protein LrgA; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidA/LrgA family. LrgA subfamily. | Response regulator LytR; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. | 0.984 |
lrgA | lytS | SERP2026 | SERP2024 | Holin-like protein LrgA; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidA/LrgA family. LrgA subfamily. | Sensor histidine kinase LytS; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. | 0.979 |
lrgB | lrgA | SERP2027 | SERP2026 | lrgB protein; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidB/LrgB family. LrgB subfamily. | Holin-like protein LrgA; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidA/LrgA family. LrgA subfamily. | 0.998 |
lrgB | lytR | SERP2027 | SERP2025 | lrgB protein; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidB/LrgB family. LrgB subfamily. | Response regulator LytR; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. | 0.979 |
lrgB | lytS | SERP2027 | SERP2024 | lrgB protein; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidB/LrgB family. LrgB subfamily. | Sensor histidine kinase LytS; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. | 0.971 |
lytR | cidB | SERP2025 | SERP2116 | Response regulator LytR; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. | Conserved hypothetical protein TIGR00659; Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidAB proteins. When a cell is stressed by the addition of antibiotics or by other factors in the environment, the CidAB proteins possibly oligomerize within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are a [...] | 0.441 |
lytR | lrgA | SERP2025 | SERP2026 | Response regulator LytR; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. | Holin-like protein LrgA; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidA/LrgA family. LrgA subfamily. | 0.984 |
lytR | lrgB | SERP2025 | SERP2027 | Response regulator LytR; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. | lrgB protein; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidB/LrgB family. LrgB subfamily. | 0.979 |
lytR | lytS | SERP2025 | SERP2024 | Response regulator LytR; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. | Sensor histidine kinase LytS; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. | 0.999 |
lytS | agrA | SERP2024 | SERP1493 | Sensor histidine kinase LytS; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. | Accessory gene regulator protein A; Required for high-level post-exponential phase expression of a series of secreted proteins. | 0.546 |
lytS | arlR | SERP2024 | SERP0989 | Sensor histidine kinase LytS; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. | DNA-binding response regulator ArlR; Member of the two-component regulatory system ArlS/ArlR. | 0.436 |
lytS | cidB | SERP2024 | SERP2116 | Sensor histidine kinase LytS; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. | Conserved hypothetical protein TIGR00659; Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidAB proteins. When a cell is stressed by the addition of antibiotics or by other factors in the environment, the CidAB proteins possibly oligomerize within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are a [...] | 0.676 |
lytS | lrgA | SERP2024 | SERP2026 | Sensor histidine kinase LytS; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. | Holin-like protein LrgA; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidA/LrgA family. LrgA subfamily. | 0.979 |