STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdsAannotation not available (260 aa)    
Predicted Functional Partners:
pgsA
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family
  
 
 0.963
uppS
Isoprenyl transferase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
  
  
 0.929
dagK
Diacylglycerol kinase; Catalyzes the phosphorylation of diacylglycerol (DAG) into phosphatidic acid. Is a key enzyme involved in the production of lipoteichoic acid by reintroducing DAG formed from the breakdown of membrane phospholipids into the phosphatidylglycerol biosynthetic pathway (By similarity); Belongs to the diacylglycerol/lipid kinase family
     
 0.906
SE_0654
annotation not available
      0.774
frr
Ribosome-recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
 
  
 0.752
SE_0938
annotation not available
 
    0.685
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP
  
  
 0.652
mprF
Phosphatidylglycerol lysyltransferase; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with pos [...]
   
  
 0.614
proS
Proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacy [...]
       0.609
rpsB
annotation not available
     
 0.534
Your Current Organism:
Staphylococcus epidermidis ATCC12228
NCBI taxonomy Id: 176280
Other names: S. epidermidis ATCC 12228, Staphylococcus epidermidis ATCC 12228, Staphylococcus epidermidis ATCC12228
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